Results 1 to 10 of about 2,134 (160)

Assessing the limitations of paraformaldehyde fixation for accurate cell surface receptor measurement [PDF]

Frontiers in Pharmacology
IntroductionQuantifying cell surface receptors, distinct from the total cellular receptor pool, which includes both intracellular and membrane-bound compartments, is imperative in cell biology and pharmacology.
Emma Bernard, Amandine Wahart, Nicolas Pataluch, Céline Galés, Véronique Pons   +4 more
doaj   +2 more sources

Computational Identification and 3D Morphological Characterization of Renal Glomeruli in Optically Cleared Murine Kidneys

Sensors, 2021
The aim of this study was to establish an accessible methodology for the objective identification and 3D morphological characterization of renal glomeruli in mice.
Nabil Nicolas, Nour Nicolas, Etienne Roux   +2 more
doaj   +1 more source

3D imaging and morphometric descriptors of vascular networks on optically cleared organs

iScience, 2023
Summary: The vascular system is a multi-scale network whose functionality depends on its structure, and for which structural alterations can be linked to pathological shifts.
Nabil Nicolas, Virginie Dinet, Etienne Roux   +2 more
doaj   +1 more source

Obésité et maladies cardiovasculaires [PDF]

médecine/sciences, 2003
Available evidence clearly indicates a rapid progression in the prevalence of obesity worldwide. As a consequence, there has also been a marked increase in the prevalence of type 2 diabetes all over the world and this chronic metabolic disease is now considered as a coronary heart disease risk equivalent.
Poirier, Paul, Després, Jean-Pierre
openaire   +2 more sources

Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Cell Death and Disease, 2021
Cyclic adenosine monophosphate (cAMP) is a master regulator of mitochondrial metabolism but its precise mechanism of action yet remains unclear. Here, we found that a dietary saturated fatty acid (FA), palmitate increased intracellular cAMP synthesis ...
Marion Laudette, Yannis Sainte-Marie, Grégoire Cousin, Dorian Bergonnier, Ismahane Belhabib, Stéphanie Brun, Karina Formoso, Loubna Laib, Florence Tortosa, Camille Bergoglio, Bertrand Marcheix, Jan Borén, Olivier Lairez, Jérémy Fauconnier, Alexandre Lucas, Jeanne Mialet-Perez, Cédric Moro, Frank Lezoualc’h   +17 more
doaj   +1 more source

Exploring the Role of PI3P in Platelets: Insights from a Novel External PI3P Pool

Biomolecules, 2023
Phosphoinositides (PIs) play a crucial role in regulating intracellular signaling, actin cytoskeleton rearrangements, and membrane trafficking by binding to specific domains of effector proteins.
Abdulrahman Mujalli, Julien Viaud, Sonia Severin, Marie-Pierre Gratacap, Gaëtan Chicanne, Karim Hnia, Bernard Payrastre, Anne-Dominique Terrisse   +7 more
doaj   +1 more source

Relation entre Maladies Parodontales et Maladies cardiovasculaires : Revue de la littérature

Revue Malienne d’Infectiologie et de Microbiologie, 2018
Introduction : La maladie parodontale (MP) est une maladie inflammatoire complexe qui détruit les tissus de soutien de la dent (parodonte) avec une étiologie multifactorielle elle a été liée au diabète, aux obstructions chroniques des voies respiratoires,
TOGO AK, KANE AST, TRAORE H, DIABY LM, SANOGO A, DIAWARA O, DIOP A   +6 more
doaj   +3 more sources

Vésicules extracellulaires et maladies cardiovasculaires [PDF]

médecine/sciences, 2021
Les maladies cardiovasculaires constituent la principale cause de décès dans le monde. Il est donc urgent de développer de nouvelles approches pour le traitement et la détection de ces maladies. Les vésicules extracellulaires (VE) ont attiré une attention considérable au vu de leur rôle dans la communication intercellulaire. Elles régulent en effet des
Pierre-Michael Coly, Xavier Loyer
openaire   +2 more sources

Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix

Scientific Reports, 2022
Bone marrow megakaryocytes (MKs) undergo a maturation involving contacts with the microenvironment before extending proplatelets through sinusoids to deliver platelets in the bloodstream.
Antoine Oprescu, Déborah Michel, Adrien Antkowiak, Elodie Vega, Julien Viaud, Sara A. Courtneidge, Anita Eckly, Henri de la Salle, Gaëtan Chicanne, Catherine Léon, Bernard Payrastre, Frédérique Gaits-Iacovoni   +11 more
doaj   +1 more source

Estrogen Receptor and Vascular Aging

Frontiers in Aging, 2021
Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause.
Morgane Davezac, Melissa Buscato, Rana Zahreddine, Patrick Lacolley, Daniel Henrion, Francoise Lenfant, Jean-Francois Arnal, Coralie Fontaine   +7 more
doaj   +1 more source