Results 1 to 10 of about 50,034 (177)

Cytokines and Chemokines in Cerebral Malaria Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2017
Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of
Kai Matuschewski
exaly   +3 more sources

Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms [PDF]

Frontiers in Cellular and Infection Microbiology
Cerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting ...
Renato M. S. de Lima, Luana K. R. Leão, Luana C. Martins, Adelaide da C. Fonseca Passos, Evander de J. Oliveira Batista, Anderson M. Herculano, Karen R. H. M. Oliveira   +6 more
doaj   +2 more sources

A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses [PDF]

Nature Communications
Factors governing the clinical trajectory of Plasmodium falciparum infection remain an important area of investigation. Here we present transcriptomic, proteomic and metabolomic analyses comparing clinical subtypes of severe Plasmodium falciparum malaria
Rafal S. Sobota, Emily M. Stucke, Drissa Coulibaly, Jonathan G. Lawton, Bryan E. Cummings, Savy Sebastian, Antoine Dara, James B. Munro, Amed Ouattara, Abdoulaye K. Kone, Bourama Kane, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Noah T. Ventimiglia, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Fayçal Maiga, Aichatou Diawara, Amidou Traore, Ali Thera, Matthew B. Laurens, Kirsten E. Lyke, Bourema Kouriba, Ogobara K. Doumbo, Christopher V. Plowe, David R. Goodlett, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos   +32 more
doaj   +2 more sources

Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study [PDF]

BMC Pediatrics
Introduction Cerebral malaria, caused by Plasmodium falciparum, represents the most severe neurologic complication of malaria. Its association with high morbidity and mortality rates, especially among young children, underscores its clinical significance.
Banga Mseza, Patrick Kumbakulu Kumbowi, Martin Nduwimana, Desire Banga, Emmanuel Tibasima Busha, Walufu Ivan Egesa, Richard Justin Odong, Grace Ndeezi   +7 more
doaj   +2 more sources

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients [PDF]

PeerJ, 2018
Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 ...
Alassane Thiam, Sabrina Baaklini, Babacar Mbengue, Samia Nisar, Maryam Diarra, Sandrine Marquet, Mouhamadou Mansour Fall, Michel Sanka, Fatou Thiam, Rokhaya Ndiaye Diallo, Magali Torres, Alioune Dieye, Pascal Rihet   +12 more
doaj   +2 more sources

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria. [PDF]

PLoS Pathogens, 2016
Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a
Brandi D Freeman, Yuri C Martins, Oscar B Akide-Ndunge, Fernando P Bruno, Hua Wang, Herbert B Tanowitz, David C Spray, Mahalia S Desruisseaux   +7 more
doaj   +1 more source

BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA

Malang Neurology Journal, 2022
Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan, Ellen Ferlita Tirtana, Kezia Seraphine, Wienta Diarsvitri   +3 more
doaj   +1 more source

Cerebral malaria and the story of Quinine and the Fever Trees

Advances in Clinical Neuroscience & Rehabilitation, 2020
Cinchona bark was first recorded as a cure for malaria by the Spanish in Peru around 1630. A Spanish missionary allegedly learned of the treatment from the Indian natives.
JMS Pearce
doaj   +1 more source

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. [PDF]

PLoS Pathogens, 2012
Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of ...
Kouyuki Hirayasu, Jun Ohashi, Koichi Kashiwase, Hathairad Hananantachai, Izumi Naka, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Peter Parham, Hisashi Arase, Katsushi Tokunaga, Jintana Patarapotikul, Toshio Yabe   +13 more
doaj   +1 more source

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria [PDF]

, 2014
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria
Afolabi, Nathaniel K., Ajetunmobi, Wasiu A., Akinbami, Felix O., Akinkunmi, Francis, Bachmann, Julie, Brown, Biobele J., Burte, Florence, Conte, Ianina, Fernandez-Reyes, Delmiro, Kampf, Caroline, Nilsson, Peter, Omokhodion, Samuel, Orimadegun, Adebola E., Pawitan, Yudi, Pramana, Setia, Schwenk, Jochen M., Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Uhlen, Mathias, Wahlgren, Mats   +19 more
core   +3 more sources