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Current Treatment Options in Neurology, 2004 Successful management of cerebral malaria requires rapid diagnosis, initiation of appropriate antimalarial agents, and aggressive supportive care. The antimalarial used will depend on drug availability, with many of the most effective agents not routinely available in the US.
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NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients [PDF]
PeerJ, 2018 Background Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 ...
Alassane Thiam +12 more
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Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria. [PDF]
PLoS Pathogens, 2016 Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a
Brandi D Freeman +7 more
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BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA
Malang Neurology Journal, 2022 Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan +3 more
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Cerebral malaria and the story of Quinine and the Fever Trees
Advances in Clinical Neuroscience & Rehabilitation, 2020 Cinchona bark was first recorded as a cure for malaria by the Spanish in Peru around 1630. A Spanish missionary allegedly learned of the treatment from the Indian natives.
JMS Pearce
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Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. [PDF]
PLoS Pathogens, 2012 Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of ...
Kouyuki Hirayasu +13 more
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Brain Pathology, 1997 Malaria infection of the Central Nervous System (CNS) can cause a severe neurological syndrome termed Cerebral Malaria (CM). The central neuropathological feature of CM is the preferential sequestration of parasitised red blood cells (PRBC) in the cerebral microvasculature.
P C, Sanchetee, P P, Varma
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Surviving cerebral malaria [PDF]
Neurology, 2018 A 48-year-old man from Minnesota declined malaria prophylaxis before hunting in South Africa. Ten days after his return, he developed body aches, confusion progressing to flaccid unresponsiveness, acute liver and renal failure, shock, and thrombocytopenia. On blood smear, Plasmodium falciparum burden was 24% and fell rapidly after aggressive management.
Eelco F M, Wijdicks, John G, Park
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Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults [PDF]
PeerJ, 2016 Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria.
Yakhya Dieye +8 more
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Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria
Frontiers in Cellular and Infection Microbiology, 2021 Malaria is a major international public health problem that affects millions of patients worldwide especially in sub-Saharan Africa. Although many tests have been developed to diagnose malaria infections, we still lack reliable diagnostic biomarkers for ...
Mohamed Omar +5 more
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