Results 21 to 30 of about 966,112 (203)

Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

Journal of Experimental Medicine, 2021
Plasmodium falciparum parasites causing cerebral malaria express specific PfEMP1 proteins (group A+CM) on infected erythrocytes. Group A+CM PfEMP1s allow entry into brain microvascular endothelial cells; this causes cell swelling and drives cerebral ...
Yvonne Adams, Rebecca W. Olsen, Anja Bengtsson, Nanna Dalgaard, M. Zdioruk, S. Satpathi, P. Behera, P. Sahu, S. Lawler, K. Qvortrup, S. Wassmer, Anja M B Jensen   +11 more
semanticscholar   +1 more source

Heparin in the treatment of cerebral malaria.

Paediatrica Indonesiana, 2021
Cerebral episodes in malaria are considered to be due to thrombin in the cerebral capillaries. Heparin is beneficial in arterial thrombosis, not only on account of its anticoagulating property, but also by virtue of its slight vasodilating effect which ...
Muzief Munir, H. Tjandra, Rampengan Th, I. Mustadjab, Wulur Fh   +4 more
semanticscholar   +1 more source

Association of Plasma Tau With Mortality and Long-term Neurocognitive Impairment in Survivors of Pediatric Cerebral Malaria and Severe Malarial Anemia

JAMA Network Open, 2021
Key Points Question Are plasma tau levels associated with long-term neurocognitive impairment in pediatric cerebral malaria or severe malarial anemia? Findings In this cohort study of 467 children in Uganda, including children with cerebral malaria and ...
D. Datta, P. Bangirana, R. Opoka, A. Conroy, Katrina Co, Caitlin Bond, Yi Zhao, K. Kawata, A. Saykin, C. John   +9 more
semanticscholar   +1 more source

The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria

Frontiers in Cellular and Infection Microbiology, 2021
Cerebral malaria (CM) is a severe neurological complication of malaria caused by the Plasmodium falciparum parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa.
N. Andoh, B. Gyan
semanticscholar   +1 more source

Pathophysiology and neurologic sequelae of cerebral malaria

Malaria Journal, 2020
Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and neurocognitive deficits profoundly affecting their quality of life.
N. Schiess, Andres Villabona-Rueda, Karissa E. Cottier, Katherine Huether, J. Chipeta, M. Stins   +5 more
semanticscholar   +1 more source

Association of ADAMTS13 polymorphism with cerebral malaria

Malaria Journal, 2011
Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of ...
Kraisin Sirima, Naka Izumi, Patarapotikul Jintana, Nantakomol Duangdao, Nuchnoi Pornlada, Hananantachai Hathairad, Tsuchiya Naoyuki, Ohashi Jun   +7 more
doaj   +1 more source

Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria

Clinical Infectious Diseases, 2020
Background Cerebral malaria is a common presentation of severe Plasmodium falciparum infection and remains an important cause of death in the tropics. Key aspects of its pathogenesis are still incompletely understood, but severe brain swelling identified
P. Sahu, A. Hoffmann, Megharay Majhi, Rajyabardhan Pattnaik, C. Patterson, K. Mahanta, A. Mohanty, R. Mohanty, S. Joshi, Anita Mohanty, Jabamani Bage, Sameer Maharana, A. Seitz, M. Bendszus, S. Sullivan, I. Turnbull, A. Dondorp, Himanshu Gupta, L. Pirpamer, S. Mohanty, S. Wassmer   +20 more
semanticscholar   +1 more source

Macrophage migration inhibitory factor is associated with mortality in cerebral malaria patients in India

BMC Research Notes, 2009
Background Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases.
Udhayakumar Venkatachalam, Dash Aditya P, Stiles Jonathan K, Nagpal Avinash C, McClintock Shannon, Jain Vidhan, Singh Neeru, Lucchi Naomi W   +7 more
doaj   +1 more source

Cerebral Malaria in a Patient with Recent Travel to the Congo Presenting with Delirium: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum. 1 Historically, cerebral malaria has been seen more frequently in children rather than adults.
Megan T. Roberson, Austin T. Smith
doaj   +1 more source

Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Frontiers in Molecular Biosciences, 2022
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan, Funmilola Adesodun Fisusi, Olufunso Bayo Adeoye   +2 more
doaj   +1 more source