Results 31 to 40 of about 966,112 (203)

RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Malaria is a deadly disease affecting hundreds of millions of people. Cerebral malaria is a type of severe disease with a high mortality rate.
Xiao He, Alison W. Ashbrook, Yang Du, Jian Wu, Hans-Heinrich Hoffmann, Cui Zhang, L. Xia, Yu-chih Peng, Keyla C. Tumas, B. Singh, Chen-feng Qi, T. Myers, C. Long, Chengyu Liu, Rongfu Wang, C. Rice, X. Su   +16 more
semanticscholar   +1 more source

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite

Biology Open, 2020
Cerebral malaria caused by Plasmodium falciparum is the severest form of the disease resulting in the morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality of cerebral malaria ...
Malabika Chakrabarti, Deepika Kannan, Akshay Munjal, Hadi Hasan Choudhary, Satish Mishra, Shailja Singh   +5 more
doaj   +1 more source

Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non-Lethal Strains. [PDF]

Parasite Immunol
ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Lim SYM.
europepmc   +2 more sources

A HOSPITAL-BASED RETROSPECTIVE COMPARATIVE STUDY OF COMPLICATIONS, OUTCOMES, CLINICAL AND LABORATORY PARAMETERS OF MALARIA WITH AND WITHOUT NEUROLOGICAL INVOLVEMENT

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background & Objectives: Classically associated with Plasmodium falciparum, neurological complications in severe malaria is associated with increased morbidity and mortality.
Sohaib Ahmad, Nadia Shirazi, Nowneet Kumar Bhat, Minakshi Dhar, Garima Mittal, Manish Mittal, Nidhi Kaeley, Manoj Kumar   +7 more
doaj   +1 more source

BIOMOLECULAR ASPECTS AND UPDATE ON TREATMENT OF CEREBRAL MALARIA

Malang Neurology Journal, 2016
Malaria is still becoming a health problem in the world and in Indonesia. Cerebral malaria is one of many features of severe and life threatening malaria. Many hypotheses underlying the pathophysiology of cerebral malaria have been disclosed, but the one
Machlusil Husna, Bowo Hery Prasetyo
doaj   +1 more source

Human immunodeficiency virus infection and cerebral malaria in children in Uganda: a case-control study

BMC Pediatrics, 2011
Background Human immunodeficiency virus (HIV)-1 infection increases the burden of malaria by increasing susceptibility to infection and decreasing the response to malarial treatment.
Byarugaba Justus, Musoke Philippa, Imani Peace D, Tumwine James K   +3 more
doaj   +1 more source

Association of cerebral malaria and TNF-α levels: a systematic review

BMC Infectious Diseases, 2020
Background Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria.
L. Leão, Bruna Puty, M. Dolabela, M. Póvoa, Yago Gecy de Sousa Né, Luciana Guimarães Eiró, N. Fagundes, L. Maia, R. R. Lima   +8 more
semanticscholar   +1 more source

A rare case of young stroke in 16 years old female with Plasmodium vivax malaria infection

Journal of Integrated Health Sciences, 2017
Malaria is the most important parasitic disease in the world, in terms of both prevalence and mortality. Infection rate is high due to raise of strains resistant to the antimalarial medicines & social factors.
N U Gediya, M K Marvaniya, D A Parmar, U S Gediya   +3 more
doaj   +1 more source

A case report of pitfall of fever and altered mental status: cerebral malaria due to in an adult traveler returning from Congo [PDF]

Journal of Neurocritical Care, 2023
Background Cerebral malaria, caused by Plasmodium falciparum, can lead to severe neurological complications. It is more frequently observed in children than in adults.
Soo-Hyun Park, Yerim Kim, Yeo Jin Kim, Jong Seok Bae, Ju-Hun Lee   +4 more
doaj   +1 more source

CD8+ T cells and human cerebral malaria: a shifting episteme.

Journal of Clinical Investigation, 2020
Mosquito-transmitted Plasmodium falciparum infection can cause human cerebral malaria (HCM) with high mortality rates. The abundance of infected red blood cells that accumulate in the cerebral vasculature of patients has led to the belief that these ...
L. Rénia, G. Grau, S. Wassmer
semanticscholar   +1 more source