Duffy negative antigen is no longer a barrier to Plasmodium vivax--molecular evidences from the African West Coast (Angola and Equatorial Guinea). [PDF]
BACKGROUND: Plasmodium vivax shows a small prevalence in West and Central Africa due to the high prevalence of Duffy negative people. However, Duffy negative individuals infected with P.
Ochando, Jordi +33 more
core +2 more sources
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley +1 more source
Complicated vivax malaria, an often underestimated condition - Case Report
Malaria is a vector-borne disease that is endemic in 91 countries. South East Asia is the second most affected region in the world, with India carrying the highest burden of the disease.
Arumugam Aashish, Gopi Manigandan
doaj +1 more source
ama1 genes of sympatric Plasmodium vivax and P. falciparum from Venezuela differ significantly in genetic diversity and recombination frequency. [PDF]
BACKGROUND: We present the first population genetic analysis of homologous loci from two sympatric human malaria parasite populations sharing the same human hosts, using full-length sequences of ama1 genes from Plasmodium vivax and P.
Sutherland, Colin J +6 more
core +3 more sources
A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova +4 more
wiley +1 more source
Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria.
Manning Laurens +7 more
doaj +1 more source
Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections. [PDF]
Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection.
Parker-Williams, J +28 more
core +2 more sources
ABSTRACT A 35‐year‐old female presented with 5 days of fever, fatigue, and myalgia during the post‐monsoon season at Damak Hospital, Jhapa, Nepal. Clinical examination revealed fever (102.7°F), tachycardia (110 bpm), and crackles in the right lower lung field.
Santosh Basyal +7 more
wiley +1 more source
Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads
Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed.
Lucio H. Freitas-Junior +10 more
doaj +1 more source
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection [PDF]
Background: It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously.
Kimura-Sato, M +39 more
core +1 more source

