Results 71 to 80 of about 747,084 (353)

COVID-19 knowledge, beliefs, prevention behaviours and misinformation in the context of an adapted seasonal malaria chemoprevention campaign in six northern Nigerian States

Tropical Medicine and Health, 2020
Background Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine and amodiaquine is an efficacious intervention for protection of children against Plasmodium falciparum malaria during the rainy season.
Sol Richardson, Taiwo Ibinaiye, Jamilu Nikau, Olusola Oresanya, Madeleine Marasciulo, Arantxa Roca-Feltrer, Christian Rassi, Olatunde Adesoro   +7 more
doaj   +1 more source

Delivery of seasonal malaria chemoprevention with enhanced infection prevention and control measures during the COVID-19 pandemic in Nigeria, Burkina Faso and Chad: a cross-sectional study

Malaria Journal, 2022
Background Seasonal malaria chemoprevention (SMC) is a WHO-recommended intervention for children aged 3–59 months living in areas of high malaria transmission to provide protection against malaria during the rainy season.
Charlotte Ward, Abimbola Phillips, Olusola Oresanya, Gloria Olisenekwu, Ekundayo Arogunade, Azoukalné Moukénet, Honoré Beakgoubé, Vincent De Paul Allambademel, Cheick Saïd Compaoré, Adama Traoré, Jean-Bosco Ouedraogo, Yves Daniel Compaoré, Issaka Zongo, Laura Donovan, Monica Anna Decola, Helen Smith, Kevin Baker   +16 more
doaj   +1 more source

Ranking malaria risk factors to guide malaria control efforts in African highlands. [PDF]

, 2009
INTRODUCTION: Malaria is re-emerging in most of the African highlands exposing the non immune population to deadly epidemics. A better understanding of the factors impacting transmission in the highlands is crucial to improve well targeted malaria ...
Baza, Dismas, Coosemans, Marc, D'Alessandro, Umberto, Protopopoff, Natacha, Speybroeck, Niko, Van Bortel, Wim, Van Geertruyden, Jean-Pierre   +6 more
core   +4 more sources

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Small Molecule‐Induced Alterations of Protein Polyubiquitination Revealed by Mass‐Spectrometric Ubiquitome Analysis

Angewandte Chemie, EarlyView.
To monitor small molecule‐induced changes in protein polyubiquitination in an unbiased manner, we employ enrichment through tandem ubiquitin binding entities coupled to LC‐MS/MS analysis (TUBE‐MS). By applying the workflow to PROTAC, p97‐ and deubiquitinase‐inhibitor treatment of cells, we demonstrate its broad applicability and reveal the induction of
Siska Führer, Kai Gallant, Farnusch Kaschani, Markus Kaiser, Petra Janning, Herbert Waldmann, Malte Gersch   +6 more
wiley   +2 more sources

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, EarlyView.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

From efficacy to effectiveness: a comprehensive framework for monitoring, evaluating and optimizing seasonal malaria chemoprevention programmes

Malaria Journal
Background Seasonal Malaria Chemoprevention (SMC) is a highly effective intervention for preventing malaria, particularly in areas with highly seasonal transmission.
Monica Anna de Cola, Elisabeth G. Chestnutt, Sol Richardson, Matthieu Baudry, Chuks Nnaji, Taiwo Ibinaiye, Azoukalné Moukénet, Kunle Rotimi, Benoît Sawadogo, Joshua Okafor, Cheick Saïd Compaoré, Chibuzo Oguoma, Christian Rassi, Arantxa Roca-Feltrer   +13 more
doaj   +1 more source

Epidemiological risk factors for clinical malaria infection in the highlands of Western Kenya. [PDF]

, 2019
BackgroundUnderstanding the complex heterogeneity of risk factors that can contribute to an increased risk of malaria at the individual and household level will enable more effective use of control measures.
Afrane, Yaw A, Afrane, Yaw A, Essendi, Walters M, Githeko, Andrew K, Lo, Eugenia, Machani, Maxwell G, Vardo-Zalik, Anne M, Yan, Guiyun, Zhou, Guofa   +8 more
core  

Ecology: a prerequisite for malaria elimination and eradication [PDF]

, 2010
* Existing front-line vector control measures, such as insecticide-treated nets and residual sprays, cannot break the transmission cycle of Plasmodium falciparum in the most intensely endemic parts of Africa and the Pacific * The goal of malaria ...
A Bhattarai, A Kiszewski, A Saul, Anna Dornhaus, Arlyne Beeche, AY Vittor, BL Sharp, C Garrett-Jones, C Lengeler, Christian Borgemeister, CR Rodriguez-Saona, D Fish, DL Smith, DL Smith, Durland Fish, EJ Scholte, EO Lyimo, EP Odum, FO Okumu, G Giglioli, G MacDonald, G Müller, G Müller, G Zhou, Gerry F. Killeen, GF Killeen, GF Killeen, GF Killeen, GJ Devine, GJ Yang, GP Garcia, GW Fegan, H Briegel, H Mshinda, H Pates, H Ranson, H Townson, HD Trung, Heather M. Ferguson, HM Ferguson, HM Ferguson, I Bates, I Bates, I Tirados, IN Lyimo, J Cox-Singh, J Keiser, J Keiser, JA Najera, JA Patz, JA Patz, JC Beier, John E. Gimnig, JP Grieco, L Kelly-Hope, L Molineaux, L Roberts, M Coluzzi, M Rowland, MA Riehle, Michael Gottlieb, Mir S. Mulla, MJ Kirby, MN Bayoh, MT Gillies, MT Gillies, MT Gillies, NJ Govella, R Feachem, RL Kouznetsov, SJ Ceesay, TW Scott, U Fillinger, W Gu, W Gu, W Gu, WA Hawley, WP O'Meara, Y Geissbuhler   +78 more
core   +4 more sources