Results 71 to 80 of about 342,683 (247)

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, EarlyView.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

Assessing the community-level impact of group antenatal care on uptake of intermittent preventive treatment for malaria in pregnancy in Atlantique Department, Benin, 2021–2023: a cluster randomized controlled trial

Malaria Journal
Background In 2023, an estimated 36 million pregnancies occurred in malaria endemic sub-Saharan Africa, but only 44% received the WHO recommended ≥ 3 doses of intermittent preventive treatment (IPTp3).
Julie R. Gutman, Faustin Onikpo, Manzidatou Alao, Julie Niemczura, Stephanie Suhowatsky, Julie Buekens, Marie Adeyemi, Katherine Wolf, Catherine Dentinger, Alexandre Binazon, Audrey S. Eunice Amoussou, Odette Aimée Alihounou, Courtney Emerson, Ahmed Saadani Hassani, Houetohossou Camille, Cyriaque D. Affoukou, Peter J. Winch, Aurore Ogouyèmi-Hounto   +17 more
doaj   +1 more source

Spatial and Temporal Variation in Abundance of Anopheles (Diptera: Culicidae) in a Malaria Endemic Area in Papua New Guinea [PDF]

, 1997
J. L. K. Hii, Thomas Smith, A. Mai, Steve Mellor, Virginia Lewis, Neâl Alexander, M P Alpers   +6 more
openalex   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, EarlyView.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Malaria vaccine wows and seeds COVID-19 vaccine effort [PDF]

, 2021
Heidi Ledford
openalex   +1 more source

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, EarlyView.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice [PDF]

, 2018
Elizabeth K. K. Glennon, Dewi Megawati, Brandi K. Torrevillas, Isaac Ssewanyana, Liusheng Huang, Fran Aweeka, Bryan Greenhouse, L. Garry Adams, Shirley Luckhart   +8 more
openalex   +1 more source

Green‐Synthesised Nanoconjugates: Advancing Targeted Photodynamic Therapy for Lung Cancer

Chemistry &Biodiversity, EarlyView.
ABSTRACT Lung cancer is a type of cancer that develops around the airways or lungs and continues to be the leading cause of cancer‐related deaths worldwide. This has necessitated the need for innovative therapeutic strategies to overcome the limits of existing therapies such as surgery, chemotherapy and radiotherapy.
Njabulo Henry Sibanda, Anine Crous, Blassan P. George   +2 more
wiley   +1 more source

Oral Artesunate for Neonatal Malaria [PDF]

, 2010
K. Shreedhara Avabratha, L. A. Chettiyar, N. P. John   +2 more
openalex   +1 more source