Results 71 to 80 of about 976,240 (379)

Windborne long-distance migration of malaria mosquitoes in the Sahel

Nature, 2019
Over the past two decades efforts to control malaria have halved the number of cases globally, yet burdens remain high in much of Africa and the elimination of malaria has not been achieved even in areas where extreme reductions have been sustained, such
D. Huestis, A. Dao, M. Diallo, Z. L. Sanogo, D. Samaké, A. Yaro, Yossi Ousman, Y. Linton, A. Krishna, Laura M. Verú, Benjamin J. Krajacich, R. Faiman, J. Florio, J. Chapman, D. Reynolds, D. Weetman, Reed Mitchell, M. Donnelly, E. Talamas, L. Chamorro, E. Strobach, T. Lehmann   +21 more
semanticscholar   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

COVID-19 knowledge, beliefs, prevention behaviours and misinformation in the context of an adapted seasonal malaria chemoprevention campaign in six northern Nigerian States

Tropical Medicine and Health, 2020
Background Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine and amodiaquine is an efficacious intervention for protection of children against Plasmodium falciparum malaria during the rainy season.
Sol Richardson, Taiwo Ibinaiye, Jamilu Nikau, Olusola Oresanya, Madeleine Marasciulo, Arantxa Roca-Feltrer, Christian Rassi, Olatunde Adesoro   +7 more
doaj   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Integrated community case management in a peri-urban setting: a qualitative evaluation in Wakiso District, Uganda

BMC Health Services Research, 2017
Background Integrated community case management (iCCM) strategies aim to reach poor communities by providing timely access to treatment for malaria, pneumonia and diarrhoea for children under 5 years of age.
Robin Altaras, Mark Montague, Kirstie Graham, Clare E. Strachan, Laura Senyonjo, Rebecca King, Helen Counihan, Denis Mubiru, Karin Källander, Sylvia Meek, James Tibenderana   +10 more
doaj   +1 more source

Efficacy of partial spraying of SumiShield, Fludora Fusion and Actellic against wild populations of Anopheles gambiae s.l. in experimental huts in Tiassalé, Côte d'Ivoire

Scientific Reports, 2023
From August 2020 to June 2021, we assessed the efficacy of SumiShield 50WG (clothianidin), Fludora Fusion 56.25WP-SB (mixture of clothianidin and deltamethrin) and Actellic 300CS (pirimiphos-methyl) in experimental huts when partially sprayed against ...
Joseph Chabi, Aklilu Seyoum, Constant V. A. Edi, Bernard Loukou Kouassi, Yemane Yihdego, Richard Oxborough, Constant G. N. Gbalegba, Ben Johns, Sameer Desale, Seth R. Irish, John E. Gimnig, Jenny S. Carlson, Melissa Yoshimizu, Jennifer S. Armistead, Allison Belemvire, Lilia Gerberg, Kristen George, Matthew Kirby   +17 more
doaj   +1 more source

Knowledge-Attitudes-Practices About Malaria Among Communities in Southern Benin [PDF]

, 2018
Malaria still remains the main public health problem in Benin. We explored the determinants that influenced malaria treatment as well as protective behaviors, to generate a framework of useful ideas as alternative strategies against malaria.
Agbo, F. O. (Frederick), Akogbeto, M. C. (Martin), Gbenoudon, J. G. (Judith), Gnanguenon, V. (Virgile), Kpanou, C. (Casimir), Osse, R. (Razaki), Oussou, O. (Olivier), Padonou, G. G. (Germain), Sagbohan, H. (Herman), Salako, A. (Albert)   +9 more
core   +3 more sources

Malaria [PDF]

Nature Reviews Disease Primers, 2017
(Uploaded by Plazi for the Bat Literature Project) Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes.
Margaret A, Phillips, Jeremy N, Burrows, Christine, Manyando, Rob Hooft, van Huijsduijnen, Wesley C, Van Voorhis, Timothy N C, Wells   +5 more
openaire   +2 more sources

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Childhood pneumonia diagnostics: community health workers’ and national stakeholders’ differing perspectives of new and existing aids

Global Health Action, 2017
Background: Pneumonia heavily contributes to global under-five mortality. Many countries use community case management to detect and treat childhood pneumonia. Community health workers (CHWs) have limited tools to help them assess signs of pneumonia. New
Hollie Spence, Kevin Baker, Alexandra Wharton-Smith, Akasiima Mucunguzi, Lena Matata, Tedila Habte, Diana Nanyumba, Anteneh Sebsibe, Thol Thany, Karin Källander   +9 more
doaj   +1 more source