Results 121 to 130 of about 79,327 (229)

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

“Reactions in Leprosy: Updated Insights Into Pathophysiology, Clinical Spectrum, and Therapeutic Approaches—A Narrative Review”

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Reaction in leprosy is an immune‐mediated acute inflammatory episodes that occur in the natural course of Hansen's disease. Reaction can occur before, during, or after starting multidrug therapy and is a major cause of nerve damage, morbidity, and disability in affected individuals.
Bhaskar Gupta, Manesha Singh, Mohamad Goldust, Kinnor Das, Surajit Gorai, Prajwal Pudasaini, Seema Sitaula, Achyut Pokhrel, Esna Thapa, Sunil Jaiswal   +9 more
wiley   +1 more source

Routine malaria vaccination in Africa: a step toward malaria eradication?

Malaria Journal
Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities occurring in children under the age of five ...
Olivier Sibomana, John Bukuru, Sulymon A. Saka, Marie Grace Uwizeyimana, Alex Mwangi Kihunyu, Abraham Obianke, Samuel Oluwo Damilare, Lewis Tem Bueh, Beloved of God Agbelemoge, Richard Omoefe Oveh   +9 more
doaj   +1 more source

Recent advances on vaccines against malaria: A review

Asian Pacific Journal of Tropical Medicine
This review aims to summarize the currently viable vaccine strategies including the approved vaccines and the those in trials for next-generation malaria vaccines. Data on malaria vaccine development was collected through a comprehensive review.
Shiza Malik, Yasir Waheed
doaj   +1 more source

The use of transgenic parasites in malaria vaccine research

Expert Review of Vaccines, 2017
Introduction: Transgenic malaria parasites expressing foreign genes, for example fluorescent and luminescent proteins, are used extensively to interrogate parasite biology and host-parasite interactions associated with malaria pathology.
Ahmad Syibli Othman, Catherin Marin-Mogollon, Ahmed M. Salman, Blandine M. Franke-Fayard, Chris J. Janse, Shahid M. Khan   +5 more
doaj   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, Volume 43, Issue 2, Page 471-490, May 2026.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Vaccination Coverage Against Coronavirus Disease 2019 (COVID‐19) in Brazil's Indigenous Population

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Indigenous populations in Brazil were prioritized for coronavirus disease 2019 (COVID‐19) vaccination due to their increased vulnerability. The aim of the study was to describe COVID‐19 vaccination coverage among Indigenous population across Brazilian regions and Special Indigenous Health Districts (DSEIs; acronym for Distritos Sanitários ...
Nathália Mariana Santos Sansone, Patrícia Teixeira Costa, Lucas Silva Mello, Luiz Felipe Azevedo Marques, Vinícius Santiago dos Santos, Fernando Augusto Lima Marson   +5 more
wiley   +1 more source

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity.

PLoS ONE, 2019
The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials.
Jo-Anne Chan, David Wetzel, Linda Reiling, Kazutoyo Miura, Damien R Drew, Paul R Gilson, David A Anderson, Jack S Richards, Carole A Long, Manfred Suckow, Volker Jenzelewski, Takafumi Tsuboi, Michelle J Boyle, Michael Piontek, James G Beeson   +14 more
doaj   +1 more source

Global Health Implications of US Exit From WHO and Suspension of Aid

Public Health Challenges, Volume 5, Issue 2, June 2026.
Kenneth Chukwuebuka Egwu, Maryam Abdulkarim, Molly Unoh Ogbodum, Yusuff Adebayo Adebisi, Dukanwojo Beulah Suleman, Don Eliseo Lucero‐Prisno III   +5 more
wiley   +1 more source