Results 111 to 120 of about 79,327 (229)

Eradicating Malaria in Africa

Baghdad Journal of Biochemistry and Applied Biological Sciences
Background: According to the World Health Organisation (WHO), malaria remains a leading burden of illness in low- and middle-income countries accounting for 94% of cases and 95% of deaths in 2022.
Stephen O. Oyejide, Abisoye B. Ajose, Omoladun S. Ogunbayo, John O. Openibo, Opeoluwa O. Shodipe, Florence T. Onifade   +5 more
doaj   +1 more source

A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health [PDF]

, 2016
In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon ...
Allan Coukell, Carolyn Shore, Elizabeth Jungman, Kathy Talkington, Pooja Kothari, Susan K. Urahn   +5 more
core  

Ontogeny of Placental FcRn Protein During Human and Animal Pregnancy to Inform Developmental Toxicity Testing

Birth Defects Research, Volume 118, Issue 5, May 2026.
ABSTRACT Introduction Species differences exist in Fc domain‐containing molecule transfer/biodistribution to the embryo‐fetus during pregnancy. Placentation was reviewed and placental neonatal Fc receptor (FcRn) quantitation in the chorioallantoic placenta (CAP) and/or inverted yolk sac placenta (InvYSP) was investigated across species throughout ...
Christopher J. Bowman, William J. Breslin, Connie Chen, Warren Foster, Julia Hui, Beata Kusmider, Susan Laffan, Matt Myers, Lakshmi Sivaraman, Belen Tornesi, Susan Westmoreland, John M. DeSesso   +11 more
wiley   +1 more source

A New method for the capture of surface proteins in Plasmodium falciparum parasitized erythrocyte [PDF]

, 2012
Introduction: We propose a new method for the selective labeling, isolation and electrophoretic analysis of the Plasmodium falciparum protein exposed on the erythrocyte cell surface.
Ferru, Emanuela, Pantaleo, Antonella, Turrini, Francesco Michelangelo   +2 more
core  

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites [PDF]

, 2019
A highly effective vaccine that confers sterile protection to malaria is urgently needed. Immunization under chemoprophylaxis with sporozoites (CPS) consistently confers high levels of protection in the Controlled Human Malaria infection (CHMI) model. To
Bijker, Else M., Crompton, Peter D., Haks, Mariëlle C., Lorenzi, Hernan, Ottenhoff, Tom H. M., Sauerwein, Robert W., Schats, Remko, Tran, Tuan M., Venepally, Pratap, Visser, Leo   +9 more
core   +2 more sources

Guillain–Barré Syndrome After Malaria: A Case Report of a 7‐Year‐Old Child With Asymmetric Onset of Acute Motor Axonal Neuropathy

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT This case highlights that acute motor axonal neuropathy can present with asymmetric, relapsing weakness in children. In malaria‐endemic and resource‐limited settings, clinicians should consider atypical Guillain–Barré variants early, as timely recognition and treatment can significantly improve outcomes despite diagnostic and systemic ...
Muath Ibrahim Mohammed Abusaada, Mustafa Mohamed Ibrahim Ali, Muotaman Mohammed Abdalla Adam, Mohammed Hishameldeen Omer Ali, Mohamed Abdallah Mohamed Baraka, Amjad Ali Mohamedelhassan Bakheit, Khabab Abbasher Hussien Mohamed Ahmed, Isameldin Yousif Khidir Mohmed   +7 more
wiley   +1 more source

A new landscape of host–protozoa interactions involving the extracellular vesicles world [PDF]

, 2018
This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press 2018Extracellular vesicles (EVs) are released by a wide number of cells including ...
Bruno Gavinho, Combes, Dlugonska, Hart, Ingrid Evans-Osses, Izadora Volpato Rossi, Jameel Inal, Kho, Lechartier, Marcel I. Ramirez, Nten, Zingales   +11 more
core   +2 more sources

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

Targeting mucosal immunity in malaria control: the underexplored role of IgA

Frontiers in Malaria
Malaria remains a global health crisis, causing an estimated 263 million cases and 597,000 deaths in 2023. Current measures—including insecticide-treated nets, ACTs, and the RTS,S vaccine—have stalled in reducing mortality, highlighting the need for ...
Haruna Muwonge, Haruna Muwonge, Isaac Ssewanyana, Adoke Yeka, Pauline Byakika-Kibwika, Pauline Byakika-Kibwika   +5 more
doaj   +1 more source