Results 101 to 110 of about 41,093 (223)

Malaria immunology and vaccine development

, 2008
This thesis describes work undertaken by the author at the University of Oxford. Itbegins by providing an introduction to malaria infection and pathophysiology, anda review of the latest attempts to produce an effective malaria vaccine.
Thompson, Fiona Mary
core  

Malaria.

, 2005
Malaria is the most important parasitic infection in people, accounting for more than 1 million deaths a year. Malaria has become a priority for the international health community and is now the focus of several new initiatives.
Greenwood, Brian M, Bojang, Kalifa, Whitty, Christopher JM, Targett, Geoffrey AT   +3 more
core   +1 more source

T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. [PDF]

, 2011
BACKGROUND: The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa.
Osei-Kwakye, Kingsley, Emmanuel Asafo-Adjei, Patrice Dubois, Agbenyega, Tsiri, Janssens, Michel H, Apanga, Stephen, Adjei, George, Daniel Ansong, Dubois, Patrice, Janssens Michel H., Marc J J Lievens, Apanga Stephen, Owusu-Agyei Seth, Dubois Patrice, Greenwood Brian M., Brian M Greenwood, Ansong Daniel, Sylverken, Justice, Joe Cohen, Barbara M. Savarese, Vekemans Johan, Kwadwo O. Boahen, Owusu-Agyei, Seth, Alex Osei-Akoto, Naana A W Brobby, Kayan, Kingsley, Olivier, Aurelie C, Olivier Aurelie C., Owusu, Sandra K, Jongert, Erik, Lievens, Marc JJ, Antwi, Sampson, Owusu Ruth, Kwadwo O Boahen, Kingsley Kayan, Jongert Erik, Naana A. W. Brobby, Dosoo David, Savarese Barbara M., Philippe J. Moris, Kwaku P Asante, Philippe J Moris, Evans Jennifer A., Brian M. Greenwood, Stephen Apanga, Marc J. J. Lievens, Greenwood, Brian M, Michel H Janssens, Savarese, Barbara M, Sandra K. Owusu, Owusu, Ruth, Sandra K Owusu, Cohen Joe, Erik Jongert, George Adjei, Aurelie C. Olivier, Asante Kwaku P., Osei-Akoto Alex, Justice Sylverken, Jennifer A. Evans, Brobby Naana A. W., Agbenyega Tsiri, Moris Philippe J., Boahen, Kwadwo O, Cohen, Joe, Kayan Kingsley, Sampson Antwi, Sambian, David, Asante, Kwaku P, Asafo-Adjei Emmanuel, Sylverken Justice, Ansong, Daniel, Barbara M Savarese, Boahen Kwadwo O., Adjei George, Osei-Kwakye Kingsley, Kingsley Osei-Kwakye, Asafo-Adjei, Emmanuel, David Sambian, Sambian David, Moris, Philippe J, David Dosoo, Ruth Owusu, Kwaku P. Asante, Lievens Marc J. J., Vekemans, Johan, Tsiri Agbenyega, Brobby, Naana AW, Osei-Akoto, Alex, Aurelie C Olivier, Dosoo, David, Jennifer A Evans, Owusu Sandra K., Seth Owusu-Agyei, Michel H. Janssens, Antwi Sampson, Johan Vekemans, Evans, Jennifer A   +97 more
core   +1 more source

Eradicating Malaria in Africa Potentials and Challenges of Vaccine Deployment

Baghdad Journal of Biochemistry and Applied Biological Sciences
Background: According to the World Health Organisation (WHO), malaria remains a leading burden of illness in low- and middle-income countries accounting for 94% of cases and 95% of deaths in 2022.
Stephen O. Oyejide, Abisoye B. Ajose, Omoladun S. Ogunbayo, John O. Openibo, Opeoluwa O. Shodipe, Florence T. Onifade   +5 more
doaj   +1 more source

Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of resurgence: a modelling study

BMC Infectious Diseases, 2019
Background The only licensed malaria vaccine, RTS,S/AS01, has been developed for morbidity-control in young children. The potential impact on transmission of deploying such anti-infective vaccines to wider age ranges, possibly with co-administration of ...
Flavia Camponovo, Chris F. Ockenhouse, Cynthia Lee, Melissa A. Penny   +3 more
doaj   +1 more source

Development of a malaria vaccine

The Lancet, 1997
Development of an effective malaria vaccine poses a major scientific challenge both in the laboratory and in the field. Such a vaccine is necessary because of the massive disease burden of malaria in the developing world, the global spread of drug resistance, and the difficulty of sustainable control of the mosquito vector. Animal models have shown the
Kwiatkowski, D, Marsh, K
openaire   +3 more sources

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Identification of a growth-inhibitory epitope in PfRipr5, a malaria vaccine candidate against Plasmodium falciparum

Frontiers in Immunology
BackgroundThe Plasmodium falciparum Rh5-interacting protein (PfRipr) is a key component of the pentameric PTRAMP-CSS-PfRipr-CyRPA-RH5 (PCRCR) complex, which is essential for erythrocyte invasion. Antibodies against PfRipr can inhibit parasite growth, but
Hikaru Nagaoka, Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima   +3 more
doaj   +1 more source

Metal–Drug Complexes as Long‐Release Application for Antimalarial PfFNT‐Inhibitors

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
P. falciparum formate‐nitrite transporter (PfFNT) inhibitors have emerged as a novel antimalarial class with potent in vivo and liver‐stage activity. Low‐solubility metal–inhibitor complexes were prepared as potential long‐acting injectables.
Finn Tiedjens, Björn Henke, Ulrich Girreser, Regina Scherließ, Eric Beitz   +4 more
wiley   +1 more source

Is vaccination the only option for possible global malaria eradication? [PDF]

, 2006
In the last century, vaccines, together with the discovery of antibiotics have been powerful tools in the management of infectious diseases. Both were of particular importance in reducing the morbidity and mortality associated with infections prevailing ...
Tonna, Ivan
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