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Expert Opinion on Therapeutic Patents, 2023
Eradication of malaria remains one of the main aims of medicine. Despite progress in malaria treatment, mortality rate remains high, especially in the poorest parts of the world. Therefore, prevention through vaccines is fundamental and recent approval of the first effective vaccine reinforced this assumption.
Michael Quagliata +2 more
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Eradication of malaria remains one of the main aims of medicine. Despite progress in malaria treatment, mortality rate remains high, especially in the poorest parts of the world. Therefore, prevention through vaccines is fundamental and recent approval of the first effective vaccine reinforced this assumption.
Michael Quagliata +2 more
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Current Biology, 1992
The development of an effective malaria vaccine is a feasible goal. Most of the vaccines being developed today are subunit vaccines derived from selected parasite antigens or their immunologically active fragments. The precise characterization of protective immune responses against Plasmodium parasites remains a fundamental part of present research ...
M F, Good, A, Saul, P M, Graves
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The development of an effective malaria vaccine is a feasible goal. Most of the vaccines being developed today are subunit vaccines derived from selected parasite antigens or their immunologically active fragments. The precise characterization of protective immune responses against Plasmodium parasites remains a fundamental part of present research ...
M F, Good, A, Saul, P M, Graves
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Parasitology Today, 2000
Although the possibility of a live attenuated malaria vaccine has been considered, current malaria vaccine development activities are dominated by attempts to develop a subunit vaccine. Hence, it is entirely appropriate that a session of the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000, was devoted to vaccine ...
R F, Anders, A, Saul
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Although the possibility of a live attenuated malaria vaccine has been considered, current malaria vaccine development activities are dominated by attempts to develop a subunit vaccine. Hence, it is entirely appropriate that a session of the Molecular Approaches to Malaria conference, Lorne, Australia, 2-5 February 2000, was devoted to vaccine ...
R F, Anders, A, Saul
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Journal of Clinical Immunology, 1996
Significant progress has been made in the development of the malaria vaccine during the last 20 years. Ninety percent of the 300-500 million clinical cases of malaria per year worldwide occur in Africa. Thus, research must be directed toward the 1 million African children under 5 years of age who die every year of malaria.
R, Amador, M E, Patarroyo
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Significant progress has been made in the development of the malaria vaccine during the last 20 years. Ninety percent of the 300-500 million clinical cases of malaria per year worldwide occur in Africa. Thus, research must be directed toward the 1 million African children under 5 years of age who die every year of malaria.
R, Amador, M E, Patarroyo
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Experientia, 1991
Among infectious diseases caused by protozoa, malaria is still the greatest killer of children. Mortality in adults living in endemic areas is significantly lower because they frequently acquire partial or complete immunity to the major pathogen, Plasmodium falciparum.
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Among infectious diseases caused by protozoa, malaria is still the greatest killer of children. Mortality in adults living in endemic areas is significantly lower because they frequently acquire partial or complete immunity to the major pathogen, Plasmodium falciparum.
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Infectious Disease Clinics of North America, 1990
Malaria continues to be a major worldwide problem. Recent advances in our understanding of the parasite and the immune response to malarial infections has resulted in major advances in the progress toward an effective malaria vaccine. Owing to the complexity of the parasite's life cycle, an effective vaccine will most assuredly contain components ...
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Malaria continues to be a major worldwide problem. Recent advances in our understanding of the parasite and the immune response to malarial infections has resulted in major advances in the progress toward an effective malaria vaccine. Owing to the complexity of the parasite's life cycle, an effective vaccine will most assuredly contain components ...
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Public Health, 1985
Abstract With the failure of eradication programmes and an exponential rise in the number of persons infected, a malaria vaccine has become a main solution to the control of malaria infection. Early work with birds, rodents and non-human primates gave encouraging results for the development of stage-specific vaccines.
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Abstract With the failure of eradication programmes and an exponential rise in the number of persons infected, a malaria vaccine has become a main solution to the control of malaria infection. Early work with birds, rodents and non-human primates gave encouraging results for the development of stage-specific vaccines.
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Frontiers in Bioscience, 2007
More than 120 years after Alphonse Laveran's discovery of the blood-stage malaria parasite, there is no licensed malaria vaccine and malaria remains the world's most serious parasitic disease. Efforts to develop a vaccine have been thwarted by the complexity of the parasite's life cycle and the ability of the parasite to suppress and evade the immune ...
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More than 120 years after Alphonse Laveran's discovery of the blood-stage malaria parasite, there is no licensed malaria vaccine and malaria remains the world's most serious parasitic disease. Efforts to develop a vaccine have been thwarted by the complexity of the parasite's life cycle and the ability of the parasite to suppress and evade the immune ...
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Acta Tropica, 2003
Besides being a leading cause of morbidity and mortality, malaria is also a cause and consequence of rampant poverty in Africa, where current control efforts are mainly frustrated by antimalaria drug and insecticide resistance. The development of malaria vaccines is therefore a priority for Africa.
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Besides being a leading cause of morbidity and mortality, malaria is also a cause and consequence of rampant poverty in Africa, where current control efforts are mainly frustrated by antimalaria drug and insecticide resistance. The development of malaria vaccines is therefore a priority for Africa.
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Perspectives for malaria vaccination
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984Abstract The need for vaccines to relieve the current global resurgence of m alaria is apparent. Immunity is specific for each species of hum an m alaria and for each stage in the life cycle. Once protective immunogens have been identified for one species, the homologous molecules in other species may lead to protection.
L H, Miller, P H, David, T J, Hadley
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