Results 161 to 170 of about 93,889 (197)

The Use of MALDI-MSI in the Investigation of Psychiatric and Neurodegenerative Disorders: A Review [PDF]

Proteomics, 2016
Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of molecular signatures in health and disease in the anatomical context.
Bernhard Baune, Peter Hoffmann, Florian Weiland   +2 more
exaly   +6 more sources

Comparing DESI-MSI and MALDI-MSI Mediated Spatial Metabolomics and Their Applications in Cancer Studies

Frontiers in Oncology, 2022
Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes and prognosis. As a result, studies continue to focus on identifying new biomarkers and metabolic vulnerabilities, both of which depend on the understanding of altered metabolism in cancer.
Donge Tang
exaly   +4 more sources

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Specific MALDI-MSI: TAG-MASS

2010
MALDI imaging as a molecular mass spectrometry imaging technique (MSI) can provide accurate information about molecular composition on a surface. The last decade of MSI development has brought the technology to clinical and biomedical applications as a complementary technique of MRI and other molecular imaging.
Jonathan, Stauber, Mohamed El, Ayed, Maxence, Wisztorski, Michel, Salzet, Isabelle, Fournier   +4 more
openaire   +2 more sources

Applications of MALDI-MSI to Pharmaceutical Research

2010
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in ...
Brendan, Prideaux, Dieter, Staab, Markus, Stoeckli   +2 more
openaire   +2 more sources

Tissue MALDI Mass Spectrometry Imaging (MALDI MSI) of Peptides

2015
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a technique to visualize molecular features of tissues based on mass detection. This chapter focuses on MALDI MSI of peptides and provides detailed operational instructions for sample preparation of cryoconserved and formalin-fixed paraffin-embedded (FFPE) tissue ...
Birte, Beine, Hanna C, Diehl, Helmut E, Meyer, Corinna, Henkel   +3 more
openaire   +2 more sources

The putative role of MALDI-MSI in the study of Membranous Nephropathy

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment.
Smith, A, L'Imperio, V, Ajello, E, Ferrario, F, Mosele, N, Stella, M, Galli, M, Chinello, C, Pieruzzi, F, Spasovski, G, Pagni, F, Magni, F   +11 more
openaire   +3 more sources

Multigrid MALDI mass spectrometry imaging (mMALDI MSI)

Analytical and Bioanalytical Chemistry, 2016
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is an important technique for the spatially resolved molecular analysis of tissue sections. The selection of matrices influences the resulting mass spectra to a high degree.
Annett, Urbanek, Stefan, Hölzer, Katrin, Knop, Ulrich S, Schubert, Ferdinand, von Eggeling   +4 more
openaire   +2 more sources

Machine learning approaches in MALDI-MSI: clinical applications

Expert Review of Proteomics, 2016
Despite the unquestionable advantages of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging in visualizing the spatial distribution and the relative abundance of biomolecules directly on-tissue, the yielded data is complex and high dimensional.
Manuel Galli, Italo Zoppis, Andrew Smith, Fulvio Magni, Giancarlo Mauri   +4 more
openaire   +2 more sources

Discriminator for Cutaneous Leishmaniasis Using MALDI-MSI in a Murine Model

Journal of the American Society for Mass Spectrometry, 2022
Cutaneous leishmaniasis is a skin disease caused by flagellate protozoa of the genus Leishmania and transmitted by sandflies of the genus Lutzomyia. Around 1 million new cases occur in the world annually, with a total of 12 million people affected, mainly in rural areas with low access to health services and adequate treatments.
Crisostomo Barajas-Solano, Betsy Muñoz, Eduardo Chicano-Gálvez, Patricia Escobar, Enrique Mejía-Ospino   +4 more
openaire   +2 more sources

MALDI‐MSI: Insights Into Plant, Cell and Environment

Plant, Cell & Environment
Summary statement MALDI‐MSI overcomes the homogenization bottleneck of conventional omics by enabling the in situ visualization of metabolites while preserving native tissue architecture. This spatial perspective reveals metabolic heterogeneity, offering key insights into plant environment adaptation mechanisms.
Hua Guo, Ran Wu, Xiaodong Wang
openaire   +2 more sources