Results 171 to 180 of about 93,889 (197)

In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)

Analytica Chimica Acta, 2014
The analysis of impurities and degradation products in pharmaceutical preparations are usually performed by chromatographic techniques such as high-performance liquid chromatography (HPLC). This approach demands extensive analysis time, mostly due to extraction and separation phases.
Lívia Riberti, Rodrigues, Diogo Noin, de Oliveira, Mônica Siqueira, Ferreira, Rodrigo Ramos, Catharino   +3 more
openaire   +2 more sources

MALDI-MSI: A Potential Game Changer in Forensic Sciences

Forensic Science, Medicine, and Pathology
Matrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination. It detects a wide range of biomolecules in their native state without specific tags, antibodies, labels, and dyes.
Asma, Jamshaid, Saadia, Noreen, Tanveer, Khalid   +2 more
exaly   +3 more sources

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

ABSTRACT The increasing interest in the role of sphingolipids in (patho)physiology has led to the demand for visualization of these lipids within tissue samples (both from animal models and patient specimens) using techniques such as matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).
Bo Chen, Ranjana Pathak, Albar Subekti, Xiaolu Cheng, Sukhjit Singh, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Chiara Luberto, Daniel Canals   +8 more
openaire   +2 more sources

Visualization of single-cell lipidomes with MALDI-MSI

Lipids are central to cellular structure, metabolism, and signaling, and yet their distribution within and across cells is highly heterogeneous. Traditional bulk mass spectrometry masks this diversity, whereas single-cell lipidomics can uncover distinct lipid configurations that define cellular states and organize tissues.
Maillat, Jean Andrea, Goršek, Nika, Barahtjan, Pavel, D'Angelo, Giovanni   +3 more
openaire   +2 more sources

Recent Technological Developments in MALDI-MSI Based Hair Analysis

2019
Hair is a common piece of trace evidence found at a crime scene, however, often it is not possible to obtain DNA (due to the lack of a follicular root). These hair samples could potentially provide other intelligence, based on the molecular history of an individual that it contains.
Flinders, Bryn, Bassindale, Tom, Heeren, Ron   +2 more
openaire   +2 more sources

Recent Advances in On‐Tissue Chemical Derivatization Strategies for Enhancing MALDI‐MSI

Mass Spectrometry Reviews
ABSTRACT Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) has rapidly advanced in biomedical research, enabling label‐free, untargeted spatial detection of metabolites, lipids, proteins, and glycans in tissue sections. However, challenges such as low ionization efficiency and chemical instability limit
Meng Huang, Xiaoyu Qi, Dafu Zhu, Hao Zhou, Jie Yuan, Danijela Mišić, Marina Soković, Hongxi Xu, Lu Sun, Yang Ye, Jia Liu   +10 more
openaire   +3 more sources

Recent Developments of Novel Matrices and On-Tissue Chemical Derivatization Reagents for MALDI-MSI

Analytical and Bioanalytical Chemistry, 2021
Carsten Hopf, Annabelle Fülöp, Qiuqin Zhou   +2 more
exaly  

MALDI-MSI zeigt EVAR-induzierte Aortenwandinstabilität

Gefässchirurgie, 2022
Matthias Buerger, Jan Paul Frese, Sebastian Kapahnke, Elena Kaschina, Manuela Sommerfeld, Oliver Klein, Ben Raude, Adrian Mahlmann, Andreas Greiner, Irene Hinterseher   +9 more
openaire   +1 more source

System klasyfikacji danych obrazowania molekularnego MALDI-MSI [PDF]

, 2022
Pendziałek, Paweł, Polańska, Joanna
openaire   +1 more source

A Reliable and Effective Sample Preparation Protocol of MALDI-TOF-MSI for Lipids Imaging Analysis in Hard and Dry Cereals

Food Chemistry, 2023
Yan-Ping Shi
exaly