Results 51 to 60 of about 93,889 (197)

MALDI-MSI-LC-MS/MS Workflow for Single-Section Single Step Combined Proteomics and Quantitative Lipidomics. [PDF]

Anal Chem
We introduce a novel approach for comprehensive molecular profiling in biological samples. Our single-section methodology combines quantitative mass spectrometry imaging (Q-MSI) and a single step extraction protocol enabling lipidomic and proteomic ...
Hendriks TFE, Krestensen KK, Mohren R, Vandenbosch M, De Vleeschouwer S, Heeren RMA, Cuypers E.   +6 more
europepmc   +2 more sources

Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy [PDF]

, 2023
Two of the most promising techniques in terms of ex vivo skin imaging and quantifying are confocal Raman microscopy and MALDI-TOF mass spectrometry imaging (MALDI-TOF MSI).
Otero-Espinar, Francisco J., García Berrocoso, Teresa, Vázquez Fernández, Ezequiel, Fernández-Campos, Francisco, Otero Espinar, Francisco J., Pena Rodríguez, Eloy, Pena-Rodríguez, Eloy, Abian Moñux, Joaquín, Abian, Joaquin, Otero Espinar, Francisco Javier, García-Berrocoso, Teresa, Fernández Campos, Francisco, Otero Espinar, Francisco, Eloy Pena-Rodríguez, Teresa García-Berrocoso, Ezequiel Vázquez Fernández, Joaquin Abian, Francisco Fernández-Campos, Francisco J. Otero-Espinar   +18 more
core   +1 more source

Drosophila melanogaster chemical ecology revisited: 2-D distribution maps of sex pheromones on whole virgin and mated flies by mass spectrometry imaging

BMC Zoology, 2020
Background Sexual behavior in Drosophila melanogaster flies is greatly influenced by chemical cues. In this study, a spatial distribution of female and male sex pheromones was investigated on the surface of virgin and mated six-day-old fruit flies ...
Filip Kaftan, Purva Kulkarni, Markus Knaden, Sebastian Böcker, Bill S. Hansson, Aleš Svatoš   +5 more
doaj   +1 more source

Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer

Acta Pharmaceutica Sinica B, 2022
Accurate localization of central nervous system (CNS) drug distribution in the brain is quite challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI), owing to the ionization competition/suppression of highly ...
Shuai Guo, Kening Li, Yanwen Chen, Bin Li   +3 more
doaj   +1 more source

Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Metabolites, 2022
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies.
Andreas Dannhorn, Emine Kazanc, Gregory Hamm, John G. Swales, Nicole Strittmatter, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats   +7 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO

Advanced Science, EarlyView.
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu, Jinpo Su, Haotian Zhou, Yilin Shen, Mengke Qin, Yingjie Luo, Tiancai Wang, Zhenglin Chen, Yuanyuan Wang, Xiaokai Ma   +9 more
wiley   +1 more source

MALDI-MSI and Ovarian Cancer Biomarkers

, 2012
None
Rémi Longuespee, Charlotte Boyon, Olivier Kerdraon, Denis Vinatier, Isabelle Fournier, Robert Day, Michel Salzet   +6 more
openaire   +3 more sources

On-Tissue Derivatization of Lipopolysaccharide for Detection of Lipid A Using MALDI-MSI

Analytical Chemistry, 2020
We developed a method to directly detect and map the Gram-negative bacterial virulence factor lipid A derived from lipopolysaccharide (LPS) by coupling acid hydrolysis with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). As the structure of lipid A (endotoxin) determines the innate immune outcome during infection, the
Hyojik Yang, Courtney E. Chandler, Shelley N. Jackson, Amina S. Woods, David R. Goodlett, Robert K. Ernst, Alison J. Scott   +6 more
openaire   +5 more sources

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

Advanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu, Yunkai Li, Jianing Wang, Chengyi Xie, Lei Guo, Yanyan Chen, Thomas Ka‐Yam Lam, Shao‐Wen Shi, Kun Wang, Baoliang Chen, Zongwei Cai   +10 more
wiley   +1 more source