Results 11 to 20 of about 3,515,464 (340)

Causes and Risk Factors for Male Infertility: A Scoping Review of Published Studies

International Journal of General Medicine, 2022
Background Despite the evidence of declining sperm counts worldwide and the increasing prevalence of male infertility, there has been limited documentation of the potential causes and risk factors for male infertility.
F. Okonofua, L. Ntoimo, A. Omonkhua, Oladiran Ayodeji, Celestina Olafusi, E. Unuabonah, V. Ohenhen   +6 more
semanticscholar   +1 more source

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

Antioxidants, 2022
Reactive oxygen species (ROS) play a critical role in defining the functional competence of human spermatozoa. When generated in moderate amounts, ROS promote sperm capacitation by facilitating cholesterol efflux from the plasma membrane, enhancing cAMP ...
R. Aitken, J. Drevet, A. Moazamian, P. Gharagozloo   +3 more
semanticscholar   +1 more source

Chromosomal Abnormalities in Iranian Infertile Males who are Candidates for Assisted Reproductive Techniques [PDF]

International Journal of Fertility and Sterility, 2007
Background: The present study offers our contribution on the topic by a retrospective analysis of the prevalence of chromosomal abnormalities in a population of Iranian infertile men attending assisted reproduction programs.Materials and Methods ...
iman salahshourifar, Mohammad Ali Sadighi Gilani, Najmeh sadat Masoudi, Hamid Gourabi   +3 more
doaj   +1 more source

A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships

medRxiv, 2021
Background: Human male infertility has a notable genetic component, including well established diagnoses like Klinefelter syndrome, Y-chromosome microdeletions, and monogenic causes.
B. Houston, A. Riera-Escamilla, M. J. Wyrwoll, Albert Salas-Huetos, M. J. Xavier, L. Nagirnaja, C. Friedrich, D. Conrad, K. Aston, C. Krausz, F. Tüttelmann, M. K. O’Bryan, J. Veltman, M. Oud   +13 more
semanticscholar   +1 more source

A de novo paradigm for male infertility

Nature Communications, 2022
De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de novo mutations play an important role in severe male infertility and explain a portion of the genetic causes of this understudied ...
M. Oud, R. Smits, H. Smith, F. Mastrorosa, G. Holt, B. Houston, P. D. de Vries, B. Alobaidi, L. Batty, H. Ismail, J. Greenwood, H. Sheth, A. Mikulasova, G. Astuti, C. Gilissen, K. McEleny, H. Turner, J. Coxhead, S. Cockell, D. Braat, K. Fleischer, K. D’Hauwers, E. Schaafsma, Donald F. Liina Kenneth I. Douglas T. James M. Timothy G. Conrad Nagirnaja Aston Carrell Hotaling Jenkins Mc, D. Conrad, L. Nagirnaja, K. Aston, D. Carrell, Jim Hotaling, Timothy G. Jenkins, R. McLachlan, M. O’Bryan, P. Schlegel, M. Eisenberg, J. Sandlow, E. Jungheim, K. Omurtag, A. Lopes, S. Seixas, F. Carvalho, Susana Fernandes, A. Barros, J. Gonçalves, I. Caetano, Graça Pinto, Sónia Correia, M. Laan, M. Punab, E. R. Meyts, Niels Jørgensen, K. Almstrup, C. Krausz, K. Jarvi, L. Nagirnaja, D. Conrad, C. Friedrich, S. Kliesch, K. Aston, A. Riera-Escamilla, C. Krausz, C. Gonzaga‐Jauregui, M. Santibanez-Koref, D. J. Elliott, L. Vissers, F. Tüttelmann, M. O’Bryan, L. Ramos, M. Xavier, G. W. van der Heijden, J. Veltman   +69 more
semanticscholar   +1 more source

Epigenetics of Male Infertility: The Role of DNA Methylation

Frontiers in Cell and Developmental Biology, 2021
In recent years, a number of studies focused on the role of epigenetics, including DNA methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the knowledge concerning the gene and genome methylation and its regulation ...
J. Rotondo, C. Lanzillotti, C. Mazziotta, M. Tognon, F. Martini   +4 more
semanticscholar   +1 more source

The Microbiome, an Important Factor That Is Easily Overlooked in Male Infertility

Frontiers in Microbiology, 2022
Humankind has been interested in reproduction for millennia. Infertility, in which male factors contribute to approximately 50%, is estimated to concern over 72 million people worldwide.
Hefeng Wang, Anran Xu, Liping Gong, Zhaowen Chen, Bin Zhang, Xiuyun Li   +5 more
doaj   +1 more source

Antioxidants and Male Infertility

Antioxidants, 2022
Oxidative stress has been associated with decreased sperm quality and male infertility [...]
Ricardo Silva, David F. Carrageta, Marco G. Alves, Branca M. Silva, Pedro F. Oliveira   +4 more
doaj   +1 more source

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

The World Journal of Men's Health, 2021
It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility.
A. Agarwal, K. Leisegang, A. Majzoub, R. Henkel, R. Finelli, M. K. Panner Selvam, N. Tadros, N. Parekh, Edmund Y Ko, C. Cho, M. Arafa, M. Alves, P. Oliveira, J. Alvarez, R. Shah   +14 more
semanticscholar   +1 more source

Oxidation of Sperm DNA and Male Infertility

Antioxidants, 2021
One important reason for male infertility is oxidative stress and its destructive effects on sperm structures and functions. The particular composition of the sperm membrane, rich in polyunsaturated fatty acids, and the easy access of sperm DNA to ...
L. Rashki Ghaleno, A. Alizadeh, J. Drevet, A. Shahverdi, M. R. Valojerdi   +4 more
semanticscholar   +1 more source