Results 91 to 100 of about 37,794 (252)

Mathematical Modeling and Sensitivity Analysis of the Existence of Male Calico Cats Population Based on Cross Breeding of All Coat Colour Types

Communication in Biomathematical Sciences, 2019
The coat color of cats is normally governed by genes found on the X chromosome in both male chromosome XY and female chromosome XX. The meiosis failure in the process of gametogenesis leads to the birth of three-colored male cats caused by an excess of ...
Dani Suandi, Ira Prapti Ningrum, Amalia Nur Alifah, Nurul Izzah, Mazi Prima Reza, Imroatul Khoiriyah Muwahidah   +5 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells [PDF]

, 2010
SummaryThe switch from mitosis to meiosis is a unique feature of germ cell development. In mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers, including Stra8, but how the switch to meiosis is controlled in male ...
David Zarkower, Shosei Yoshida, Bardwell, Vivian J., Clinton K. Matson, Mark W. Murphy, Matson, Clinton K, Murphy, Mark W., Vivian J. Bardwell, Bardwell, Vivian J, Murphy, Mark W, Michael D. Griswold, Zarkower, David, Matson, Clinton K., Yoshida, Shosei, Griswold, Michael D., Griswold, Michael D   +15 more
core   +1 more source

ATR is required to complete meiotic recombination in mice

Nature Communications, 2018
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and ...
Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés, Ignasi Roig   +11 more
doaj   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Male meiosis in Crustacea: synapsis, recombination, epigenetics and fertility in Daphnia magna [PDF]

, 2015
We present the first detailed cytological study of male meiosis in Daphnia (Crustacea: Branchiopoda: Cladocera)-an aquatic microcrustacean with a cyclical parthenogenetic life cycle.
Rocío Gómez, Colbourne, John K; id_orcid, Kay Van Damme, Gosálvez, Jaime, Eugenio Sánchez Morán, Jaime Gosálvez, Van Damme, Kay, Morán, Eugenio Sánchez; id_orcid, Gómez, Rocío, John K. Colbourne   +9 more
core   +1 more source

First report on a multiple sex chromosome system (X1X2X30) and population variations in the frequency of ring bivalents in Pyrrhocoridae (Hemiptera: Heteroptera)

European Journal of Entomology, 2015
The family Pyrrhocoridae (Hemiptera: Heteroptera) is characterized by a modal diploid chromosome number of 16 (♂) ranging from 12 to 33 and simple (X0), multiple (X1X20) and neo-sex chromosome systems (neoX-neoY).
Harbhajan KAUR, Kalchana GABA
doaj   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source