Results 181 to 190 of about 34,110 (232)

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis. [PDF]

Cell Death Differ, 2020
Zhang B, Tang Z, Li L, Lu LY.
europepmc   +1 more source

Baicalin Protects Mouse Testis From Injury Induced by PM2.5 Associated With the DKK1‐Wnt/β‐Catenin Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ABSTRACT Fine particulate matter (PM2.5) has a damaging effect on the male reproductive system. Baicalin has excellent anti‐inflammatory and antioxidant pharmacological functions. The main purpose of this study was to investigate whether baicalin had a protective effect against PM2.5‐induced damage to the reproductive system of mice, and to further ...
Lili Deng, Juan Wang, Shuyin Li, Yaping Mao, Ye Sun, Qiaoqiao Yang, Zhenghui Xie, Chen Zhang, Shuo Gong, Chunling Xiao, Mingyue Ma   +10 more
wiley   +1 more source

Chromosome separation during Drosophila male meiosis I requires separase-mediated cleavage of the homolog conjunction protein UNO. [PDF]

PLoS Genet, 2020
Weber J, Kabakci Z, Chaurasia S, Brunner E, Lehner CF.   +4 more
europepmc   +1 more source

Elevated LncRNA LINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
This study identifies LINC00966 as an upregulated lncRNA in asthenozoospermia associated with reduced sperm quality. Linc00966 suppresses Pde2a, disrupts cGMP signaling, and promotes oxidative stress, thereby impairing spermatogenic cell viability and migration.
Bingrou Guo, Junyi Ke, Hanran Mai, Ting Zhang, Zhaojin Lu, Zilin Zheng, Jieyi Luo, Yifan Zhang, Mei Yan, Shuo Yang, Yanxia Qu, Fan Jiang, Xiaoping Liu, Hao Chen, Liandong Zuo   +14 more
wiley   +1 more source

Sex‐biasing gene drives for island mouse eradications: Modelling dispersal and mating behaviour for improved risk assessment preparedness

Journal of Applied Ecology, Volume 63, Issue 8, August 2026.
Though drive efficiency was highly influential to model outcomes, such parameters will likely be known prior to any experimental gene drive introductions. We conclude that understanding the ecological and life‐history characteristics specific to target populations will be critical to accurately predict gene drive outcomes and inform risk assessments ...
Matthew A. Combs, Alun L. Lloyd, Aaron B. Shiels, Antoinette J. Piaggio, Andrew J. Golnar, Kim M. Pepin   +5 more
wiley   +1 more source

AID‐Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells

Development, Growth &Differentiation, Volume 68, Issue 6, August 2026.
ABSTRACT The RNA‐binding protein NANOS2 plays a crucial role in male gonocyte development and the maintenance of spermatogonial stem cells. In the absence of the Nanos2 gene (Nanos2‐KO), germ cells fail to enter G0 arrest and initiate the male differentiation program (including DNA methylation and the piRNA pathway), ultimately undergoing apoptosis ...
Yumiko Saga, Quan Wu
wiley   +1 more source

How noncrossover homologs are conjoined and segregated in Drosophila male meiosis I: Stable but reversible homolog linkers require a novel Separase target protein. [PDF]

PLoS Genet, 2020
Adams EE, He Q, McKee BD.
europepmc   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2673-2686, August 2026.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

Crossability Relations of Domesticated Peas (Pisum sativum and Pisum abyssinicum) With Wild Pisum fulvum and Drought Response Assessment of P. sativum × P. fulvum Progenies

Plant Breeding, Volume 145, Issue 4, Page 715-728, August 2026.
ABSTRACT The productivity and quality of grain crops in semiarid environments is often affected by drought, which is likely to accentuate due to predicted climate changes. Wild pea (Pisum fulvum Sibth. & Smith) accessions are known to harbour useful allelic diversity for drought responses.
Smadar Tsury, Eran Dagan, Yehoshua Saranga, Shahal Abbo   +3 more
wiley   +1 more source