Results 21 to 30 of about 33,936 (110)

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids

Cell Reports, 2018
Summary: Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduction and sustained by spermatogonial stem cells (SSCs).
Brian P. Hermann, Keren Cheng, Anukriti Singh, Lorena Roa-De La Cruz, Kazadi N. Mutoji, I-Chung Chen, Heidi Gildersleeve, Jake D. Lehle, Max Mayo, Birgit Westernströer, Nathan C. Law, Melissa J. Oatley, Ellen K. Velte, Bryan A. Niedenberger, Danielle Fritze, Sherman Silber, Christopher B. Geyer, Jon M. Oatley, John R. McCarrey   +18 more
doaj   +1 more source

Regulation of meiotic entry and gonadal sex differentiation in the human: normal and disrupted signaling

Biomolecular Concepts, 2014
Meiosis is a unique type of cell division that is performed only by germ cells to form haploid gametes. The switch from mitosis to meiosis exhibits a distinct sex-specific difference in timing, with female germ cells entering meiosis during fetal ...
Jørgensen Anne, Rajpert-De Meyts Ewa
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The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis

Cells, 2020
The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids ...
Maria Laura Di Giorgio, Patrizia Morciano, Elisabetta Bucciarelli, Antonella Porrazzo, Francesca Cipressa, Sara Saraniero, Diana Manzi, Yikang S. Rong, Giovanni Cenci   +8 more
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Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity

Nature Communications, 2023
Male meiosis relies on canonical centrosomes for spindle formation, but how this differs from acentrosomal oocyte meiosis is unclear. Here they show that spindle formation in sperm relies on DYNLRB2, similar to the activity of DYNLRB1 in mitotic cells.
Shuwen He, John P. Gillies, Juliana L. Zang, Carmen M. Córdoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E. DeSantis, Hiroki Shibuya   +8 more
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The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C.

PLoS Biology, 2012
CENP-A (CID in flies) is the histone H3 variant essential for centromere specification, kinetochore formation, and chromosome segregation during cell division.
Elaine M Dunleavy, Nicole L Beier, Walter Gorgescu, Jonathan Tang, Sylvain V Costes, Gary H Karpen   +5 more
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The cyclin-A CYCA1;2/TAM is required for the meiosis I to meiosis II transition and cooperates with OSD1 for the prophase to first meiotic division transition. [PDF]

PLoS Genetics, 2010
Meiosis halves the chromosome number because its two divisions follow a single round of DNA replication. This process involves two cell transitions, the transition from prophase to the first meiotic division (meiosis I) and the unique meiosis I to ...
Isabelle d'Erfurth, Laurence Cromer, Sylvie Jolivet, Chloé Girard, Christine Horlow, Yujin Sun, Jennifer P C To, Luke E Berchowitz, Gregory P Copenhaver, Raphael Mercier   +9 more
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Orchestrating homolog segregation in meiosis I: molecular logic and regulatory networks with emphasis on male metaphase I

Cell Communication and Signaling
Accurate segregation of homologous chromosomes during meiosis I (MI) is essential for haploid gamete production. This review systematically summarizes the dynamic regulatory mechanisms governing chromosome segregation in male mammalian meiosis.
Xinyu Zhang, Jiahao Liu, Kai Mao, Jingsheng Xu, Xiangyin Qian, Yao Rong, Tian Tian, Kai Wei, Minjie Chu, Yan Zhang   +9 more
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A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. [PDF]

PLoS Biology, 2007
DMC1 is a meiosis-specific homolog of bacterial RecA and eukaryotic RAD51 that can catalyze homologous DNA strand invasion and D-loop formation in vitro.
Laura A Bannister, Roberto J Pezza, Janet R Donaldson, Dirk G de Rooij, Kerry J Schimenti, R Daniel Camerini-Otero, John C Schimenti   +6 more
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Recombination homeostasis of meiosis during spermatogenesis under nicotine treatment [PDF]

Archives of Biological Sciences, 2018
Cigarette smoking can affect male fertility via the quality of semen. To explore the effects of nicotine, a major component of cigarettes, on meiotic recombination during spermatogenesis, C57BL/6J male mice were injected with nicotine at a dosage of 0.2 ...
Zhai Jingli, Yuan Qingqing, Yang Tianqi, Zhao Xianglong, Zhang Meixing, Zhang Dong, Xu Wangjie, Qiao Zhongdong   +7 more
doaj   +1 more source

KIF2C is essential for meiosis and manchette dynamics in male mice

Frontiers in Cell and Developmental Biology
In gametogenesis, microtubules undergo dramatic changes known as microtubule dynamics, and which is important for fertility both male and female. In spermatogenesis, spindle microtubule dynamics occur during meiosis and manchette microtubule dynamics ...
Ryua Harima, Mayu Kishinami, Kenshiro Hara, Kentaro Tanemura, Kentaro Tanemura   +4 more
doaj   +1 more source