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Endocrinology and Metabolism Clinics of North America, 2023
Recent publications of well-conducted population studies have informed us that the syndromic prevalence of age-related low testosterone, also known as late-onset hypogonadism, is quite low. Several well-conducted trials in middle-aged and older men with age-related decline in testosterone levels have revealed that efficacy of testosterone therapy is ...
Maria Gabriela, Figueiredo +2 more
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Recent publications of well-conducted population studies have informed us that the syndromic prevalence of age-related low testosterone, also known as late-onset hypogonadism, is quite low. Several well-conducted trials in middle-aged and older men with age-related decline in testosterone levels have revealed that efficacy of testosterone therapy is ...
Maria Gabriela, Figueiredo +2 more
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2020
Exosomes are nanosized membrane vesicles secreted by wide variety of cells and found in abundance in biological fluids including semen. They contain cargo of lipids, proteins, microRNAs and mRNAs, and are known to play a major role in intracellular communication. Seminal exosomes mainly include epididymosomes and prostasomes.
Saradha, Baskaran +2 more
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Exosomes are nanosized membrane vesicles secreted by wide variety of cells and found in abundance in biological fluids including semen. They contain cargo of lipids, proteins, microRNAs and mRNAs, and are known to play a major role in intracellular communication. Seminal exosomes mainly include epididymosomes and prostasomes.
Saradha, Baskaran +2 more
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Oestrogens in male reproduction
Best Practice & Research Clinical Endocrinology & Metabolism, 2000The role of oestrogens in male reproductive physiology is rapidly being redefined. While cases of oestrogen deficiency or insensitivity are rare among humans, insights are being gained from the development of mouse models in which oestrogen action has been abolished. Four knockout mouse models are currently available.
M E, Jones, E R, Simpson
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Antivirals and Male Reproduction
2017The use of antiviral medications has increased with the recognition and treatment of HIV infections, and these drugs are the main focus of this chapter. HIV has become a chronic disease, and many men with HIV desire children. The disease itself has profound negative effects on semen quality, as does infection with hepatitis C virus (HCV), so treatment ...
Erma Z, Drobnis, Ajay K, Nangia
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Hypotaurine in Male Reproduction
1992Hypotaurine was first identified as a major amino acid of sperm by Horst and Grooten1. These studies were extended by Kochakian who demonstrated that hypotaurine was present in most rodent productive tissues and that in some tissues levels were androgen responsive2.
R P, Holmes +4 more
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Antimicrobials and Male Reproduction
2017Antibiotics have long been suspected of contributing to male infertility; however, there are remarkably limited data to support this premise. A major challenge for evaluating antibiotic effects is that the diseases they treat often have negative impacts on male reproduction, so treatment with the antimicrobial can improve reproductive endpoints.
Erma Z, Drobnis, Ajay K, Nangia
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Annual Review of Physiology, 1974
The male reproductive system consists of external reproductive organs, penis and scrotum, and internal reproductive organs: testes, a duct system, and accessory glands. The adult, paired testes produce both male sex hormones (androgens) and sperm cells (spermatogenesis).
W R, Gomes, N L, VanDemark
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The male reproductive system consists of external reproductive organs, penis and scrotum, and internal reproductive organs: testes, a duct system, and accessory glands. The adult, paired testes produce both male sex hormones (androgens) and sperm cells (spermatogenesis).
W R, Gomes, N L, VanDemark
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Immunosuppressants and Male Reproduction
2017Prolonged use of immunosuppressant medications is occasionally seen in infertile men with chronic inflammatory conditions; autoimmune disorders; or an organ or hematopoietic stem cell transplant. Chronic inflammation impacts negatively on male reproductive endpoints, so immunosuppressant therapy can produce improvements.
Erma Z, Drobnis, Ajay K, Nangia
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The Neuroendocrinology of Male Reproduction
Hospital Practice, 1979Androgen biosynthesis occurs in Leydig cells and spermatogenesis in the seminiferous tubules, but both are under control of the anterior pituitary through its secretion of gonadotropins. The hypothalamus is primarly involved in feedback control of gonadotropin secretion in response to varying blood levels of testicular hormones.
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Psychotropics and Male Reproduction
2017Psychotropic drugs, including antidepressants, antipsychotics, and anticonvulsants, all have negative effects on sexual function and semen quality. These adverse events vary among men and are less pronounced for some medications, allowing their effects to be managed to some extent.
Erma Z, Drobnis, Ajay K, Nangia
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