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Male Reproduction and Aging

Endocrinology and Metabolism Clinics of North America, 2023
Recent publications of well-conducted population studies have informed us that the syndromic prevalence of age-related low testosterone, also known as late-onset hypogonadism, is quite low. Several well-conducted trials in middle-aged and older men with age-related decline in testosterone levels have revealed that efficacy of testosterone therapy is ...
Maria Gabriela, Figueiredo   +2 more
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Melatonin and male reproduction

Clinica Chimica Acta, 2015
Melatonin is a neurohormone secreted by the pineal gland whose concentrations in the body are regulated by both the dark-light and seasonal cycles. The reproductive function of seasonal breeding animals is clearly influenced by the circadian variation in melatonin levels.
Chunjin, Li, Xu, Zhou
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Oestrogens in male reproduction

Best Practice & Research Clinical Endocrinology & Metabolism, 2000
The role of oestrogens in male reproductive physiology is rapidly being redefined. While cases of oestrogen deficiency or insensitivity are rare among humans, insights are being gained from the development of mouse models in which oestrogen action has been abolished. Four knockout mouse models are currently available.
M E, Jones, E R, Simpson
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Antivirals and Male Reproduction

2017
The use of antiviral medications has increased with the recognition and treatment of HIV infections, and these drugs are the main focus of this chapter. HIV has become a chronic disease, and many men with HIV desire children. The disease itself has profound negative effects on semen quality, as does infection with hepatitis C virus (HCV), so treatment ...
Erma Z, Drobnis, Ajay K, Nangia
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Exosomes of male reproduction

2020
Exosomes are nanosized membrane vesicles secreted by wide variety of cells and found in abundance in biological fluids including semen. They contain cargo of lipids, proteins, microRNAs and mRNAs, and are known to play a major role in intracellular communication. Seminal exosomes mainly include epididymosomes and prostasomes.
Saradha, Baskaran   +2 more
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Antimicrobials and Male Reproduction

2017
Antibiotics have long been suspected of contributing to male infertility; however, there are remarkably limited data to support this premise. A major challenge for evaluating antibiotic effects is that the diseases they treat often have negative impacts on male reproduction, so treatment with the antimicrobial can improve reproductive endpoints.
Erma Z, Drobnis, Ajay K, Nangia
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The Male Reproductive System

Annual Review of Physiology, 1974
The male reproductive system consists of external reproductive organs, penis and scrotum, and internal reproductive organs: testes, a duct system, and accessory glands. The adult, paired testes produce both male sex hormones (androgens) and sperm cells (spermatogenesis).
W R, Gomes, N L, VanDemark
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The Neuroendocrinology of Male Reproduction

Hospital Practice, 1979
Androgen biosynthesis occurs in Leydig cells and spermatogenesis in the seminiferous tubules, but both are under control of the anterior pituitary through its secretion of gonadotropins. The hypothalamus is primarly involved in feedback control of gonadotropin secretion in response to varying blood levels of testicular hormones.
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Male Reproductive Surgery

Veterinary Clinics of North America: Food Animal Practice, 1995
Copulation failure in food animals can be economically devastating to producers. Many pathological conditions can result in the inability of an animal to breed. In this article, diagnosis, pathophysiology, and treatment of penile and preputial injuries and anomalies, and inguinal hernias are presented.
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