Results 171 to 180 of about 39,650 (248)

A designer protein binder of KRAS enables exogenous protein degradation

Protein Science, Volume 35, Issue 12, December 2026.
Abstract Targeted protein degradation has emerged as a powerful strategy for modulating intracellular proteins, particularly those lacking traditional small‐molecule binding pockets. While protein‐based degraders expand this approach to undruggable targets, they typically require intracellular expression in target cells, limiting their utility as ...
Aniekan Okon, Keith M. Cheah, Oscar J. Molina, Gabriel Saenz, K. Dane Wittrup, Ronald T. Raines   +5 more
wiley   +1 more source

Disulfide rebridging platforms for site-specific ADC conjugation. [PDF]

RSC Chem Biol
Petri L, Kovács ÍK, Kiss BJ, Keserű GM.   +3 more
europepmc   +1 more source

Beyond Membrane Fusion: SNARE Proteins as Regulators of Signaling and Gene Expression

Traffic, Volume 27, Issue 4, December 2026.
Regulation of gene expression by SNAREs. Some SNAREs, including alternatively spliced isoforms, may access the nucleus where they perform various regulatory activities. These SNAREs may act as transcriptional activators or mediate/participate in the transport of transcription factors to the nucleus.
Clémentine Roux, Albert Descoteaux
wiley   +1 more source

Improving purity and apparent thermal stability of single-chain Fv antibodies by heat treatment in a soluble E. coli cytoplasmic expression system. [PDF]

J Biochem
De S, Kobashigawa Y, Okazaki K, Kamesawa S, Sato T, Morioka H.   +5 more
europepmc   +1 more source

Regioselective Diversification of Aminopyrazoles via Ir‐Catalyzed C─H Borylation

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Aminopyrazoles, an important bioactive pharmacophore, are typically accessed inefficiently through de novo syntheses that yield isomeric mixtures of 3‐ and 5‐substituted derivatives. To address this challenge, we have elaborated readily available 3‐ and 5‐aminopyrazole fragments using Ir C─H borylation, regioselectively furnishing boronates for ...
Jay S. Wright, Felipe M. Nogueira, Andrew C. Hones, Mingyan Ding, Mark A. Fox, Wender A. Silva, Angelo H. de Lira Machado, Alpay Dermenci, David C. Blakemore, Patrick G. Steel   +9 more
wiley   +1 more source

Mechanically Gated Generation of a 3<i>H</i>-Anthra[2,1-<i>b</i>]pyran Photoswitch Enabling Multicolor Switching. [PDF]

ACS Macro Lett
Sun Y, Razo WG, Robb MJ.
europepmc   +1 more source

Partially Biobased Polyurethanes With Reversibly Crosslinkable Furan Units Toward Recyclable Thermosetting Textile Fibres

Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.
A molecular design strategy combines lignin‐derived aromatic units, sugar‐derived furan groups, and flexible glycol segments to create wet‐spinnable polyurethanes. Thermally reversible Diels–Alder crosslinking chemistry enables formation of crosslinked thermosetting fibers, repeated de‐crosslinking/re‐crosslinking cycles, and tunable fiber properties ...
Rafael N. L. Menezes, Fredrik Bäcklund, Tam T. Nguyen, Maria Maukonen, Zengwei Guo, Olga Gordivska, Cecilia Hansson, Baozhong Zhang   +7 more
wiley   +1 more source

Hybrid Dynamic-Covalent PEG Hydrogels With Enhanced Stability for Photothermally Triggered Pulsatile Drug Delivery. [PDF]

Macromol Biosci
Thapa K, Scott A, Otakpor MU, Bhuiyan SH, Conrad N, Torres E, Gee D, Afiza M, Rosales AM, Betancourt T.   +9 more
europepmc   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, Volume 29, Issue 41, 3 November 2026.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Congenital Dyserythropoietic Anemia Type II Caused by a New <i>SEC23B</i> Sequence Variant. [PDF]

Case Rep Hematol
Tjønnfjord GE, Loraas A, Spetalen S, Osnes LTN, Tveten K.   +4 more
europepmc   +1 more source