Results 191 to 200 of about 39,650 (248)

Quantitative and amino acid sequence analysis of soluble HIV‐1 Vpu and calmodulin interactions

Protein Science, Volume 35, Issue 11, November 2026.
Abstract HIV‐1 Vpu supports viral adaptation through host‐protein interactions. Although mainly membrane‐associated, we recently identified a soluble Vpu form that forms a stable complex with Ca2+‐bound calmodulin (Ca2+–CaM), potentially influencing Vpu trafficking. Here, to determine the binding affinity and identify regions of soluble Vpu involved in
Adeyemi Ogunbowale, Elaheh Hadadianpour, Olamide Ishola, Md Majharul Islam, Natalie Ramos, Arvin Saffarian Delkhosh, Elka R. Georgieva   +6 more
wiley   +1 more source

Mechanochemical Diastereoselective Substrate-Directed Synthesis of Pyrrole-Isoxazolidines via 1,3-Dipolar Cycloaddition of Maleimides with Nitrones. [PDF]

J Org Chem
de Jesus IS, Lédo AFDC, Ferrer A, A Bueno M, Cunha S.   +4 more
europepmc   +1 more source

Pulling and gripping: Proteasomal translocation pathway elements differentially contribute to substrate unfolding

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Eukaryotic proteomes are regulated by the ubiquitin‐proteasome system. Unwanted proteins are tagged with ubiquitin, which is recognized by the 26S proteasome for degradation. To enter the proteasome's 20S core particle and be hydrolyzed into peptides, the substrate must be unfolded and threaded through the 19S regulatory particle.
Edwin R. Ragwan, Kristi M. Pham, Arushi Palta, Destiny N. McWilliams, Daniel A. Kraut   +4 more
wiley   +1 more source

Peptide-functionalized gadolinium liposomes enable HER2-targeted molecular MRI of breast cancer. [PDF]

Nanoscale Adv
Monti S, Gallo E, Ferrara Y, Verdoliva V, Licenziato L, Terlizzi C, Sarnella A, Albanese S, Avagliano C, Accardo A, Greco A, De Luca S.   +11 more
europepmc   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Diels-Alder Reactions in [Pd₆L₄]¹²⁺ Metallocages: The Key Roles of Preorganization and Confinement. [PDF]

Inorg Chem
Sciortino G, Cuesta I, Norjmaa G, Ujaque G.   +3 more
europepmc   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Near-Infrared Fluorescence Imaging and Photothermal Therapy of Tumors Using a Targeted Helical Protein Scaffold. [PDF]

ACS Appl Bio Mater
Carrillo-Malani N, Ho G, Liang Q, Miller J, Busch TM, Amirshaghaghi A, Cheng Z, Tsourkas A.   +7 more
europepmc   +1 more source

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua, Alberto Luridiana, Francesco Secci, Emanuele Cocco   +3 more
wiley   +1 more source

Catalyst-Free Green Synthesis of Dithiocarbamate and Rhodanine Derivatives via C─S and C─N Bond Formation Using N-Substituted Maleimides. [PDF]

Chem Asian J
Satani P, Soliya S, Dutta S, Naveen T.
europepmc   +1 more source