Results 201 to 210 of about 39,650 (248)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

open access: yesChemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Performance Optimization and Prospects of Double Network Hydrogels for Flexible Electronic Devices

open access: yesChemElectroChem, Volume 13, Issue 20, 16 October 2026.
This review provides a comprehensive overview of DN hydrogels, focusing on their classification, key properties, and diverse applications. Based on crosslinking mechanisms, DN hydrogels are categorized into chemically crosslinked, physically crosslinked, and hybrid crosslinked systems, each offering distinct advantages in stability, reversibility, and ...
Liu Xing   +8 more
wiley   +1 more source

Redox-responsive polymeric nanocarriers for targeted delivery of bruceantin to pancreatic cancer. [PDF]

open access: yesNanoscale
Workie YA   +12 more
europepmc   +1 more source

Rational Engineering of Cellobiose Dehydrogenase via Substrate Pocket Redesign and Electron Transfer Optimization for Efficient Bioelectrosynthesis of Lactobionic Acid

open access: yesChemElectroChem, Volume 13, Issue 20, 16 October 2026.
Structure‐guided substrate‐pocket engineering and electron‐transfer optimization are integrated to enhance cellobiose dehydrogenase for lactose oxidation. The N313D mutation strengthens substrate‐binding interactions, and A165C and W316H improve electron transfer.
Xinyu Cui   +6 more
wiley   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy   +7 more
wiley   +2 more sources

Toward Ideal Proximity‐Driven Reactions in Chemical Biology

open access: yesChemBioChem, Volume 27, Issue 19, 14 October 2026.
Building on established principles of molecular templation, this perspective explores how molecular recognition can control chemical reactivity in space and time and outlines the design principles of an ideal proximity‐driven reaction for chemical biology.
Dominik Schauenburg
wiley   +1 more source

Synthesis of Cysteine–Fluorophore Conjugates by Visible‐Light‐Promoted Thiol–Ene Coupling Using Organic Photocatalysts

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Cysteine–fluorophore conjugates were efficiently prepared through a visible‐light‐driven thiol–ene approach employing solely organic photocatalysts. The reaction proceeds under mild, metal‐free conditions. The fluorophore scope includes mono‐ and dialkene‐functionalized naphthalene, naphthalimide, and aromatic diimide derivatives.
Julieth Bellaizac‐Riascos   +4 more
wiley   +1 more source

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