Results 1 to 10 of about 175,504,466 (285)

Response to Antiseizure Medications in Epileptic Patients With Malformation of Cortical Development [PDF]

Therapeutic Advances in Neurological Disorders, 2021
Background: Malformation of cortical development (MCD) is one of the most common causes of pharmacoresistant epilepsy. Improving the knowledge of antiseizure medications (ASMs) treatment response in epileptic patients with MCD is crucial for optimal ...
Shuang Wang, Cong Chen, Yao Ding
exaly   +3 more sources

Hemimegalencephaly: A rare congenital malformation of cortical development [PDF]

Clinical Case Reports, 2021
Hemimegalencephaly is a rare congenital malformation of cortical development usually associated with developmental delay and refractory epilepsy that sooner or later require hemispherectomy.
Vikash Jaiswal, Muhammad Hanif, Zouina Sarfraz, Gaurav Nepal, Sidra Naz, Dattatreya Mukherjee, Samir Ruxmohan   +6 more
doaj   +2 more sources

Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy [PDF]

Epilepsia Open, 2023
Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new and rare histopathological entity of cortical developmental malformations.
Xianyu Liu, Ying Zhu, Qingzhu Liu, Shuang Zhang, Pengxia Wu, Yu Sun, Jie Zhang, Ruofan Wang, Taoyun Ji, Shuang Wang, Xiaoyan Liu, Yuwu Jiang, Lixin Cai, Ye Wu   +13 more
doaj   +2 more sources

In vivo MRI Successfully Reveals the Malformation of Cortical Development in Infant Rats [PDF]

Frontiers in Neuroscience, 2020
Objective: Malformations of cortical development (MCDs) are major causes of intractable epilepsies. To characterize the early neuroimaging findings of MCDs, we tried to identify the MRI features consistent with pathological findings in an infant rat MCD ...
Minyoung Lee, Minyoung Lee, Eun-Jin Kim, Dong-Cheol Woo, Woo-Hyun Shim, Woo-Hyun Shim, Mi-Sun Yum, Mi-Sun Yum   +7 more
doaj   +2 more sources

Prenatal (1–3)IGF‐1 Treatment Is Ineffective and Behaviorally Detrimental in a Rat Model of Cortical Malformation [PDF]

Brain and Behavior
Background Malformations of cortical development (MCD), a major cause of early‐onset epilepsy, arise from disruptions in fetal corticogenesis, suggesting that prenatal intervention may be required to alter their developmental trajectory.
Minyoung Lee, Eun‐Jin Kim, Mi‐Sun Yum   +2 more
doaj   +2 more sources

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

eLife, 2021
Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton.
Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir   +10 more
doaj   +1 more source

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Diagnostics, 2023
Focal cortical dysplasia (FCD) represents a heterogeneous group of morphological changes in the brain tissue that can predispose the development of pharmacoresistant epilepsy (recurring, unprovoked seizures which cannot be managed with medications). This
Dimitar Metodiev, Krassimir Minkin, Margarita Ruseva, Rumiana Ganeva, Dimitar Parvanov, Sevdalin Nachev   +5 more
doaj   +1 more source

Malformations of cortical development: genetic mechanisms and diagnostic approach [PDF]

Korean Journal of Pediatrics, 2017
Malformations of cortical development are rare congenital anomalies of the cerebral cortex, wherein patients present with intractable epilepsy and various degrees of developmental delay. Cases show a spectrum of anomalous cortical formations with diverse
Jeehun Lee
doaj   +1 more source

Diffusion tensor imaging discriminates focal cortical dysplasia from normal brain parenchyma and differentiates between focal cortical dysplasia types

Insights into Imaging, 2023
Key points 1. DTI derived indices may be a useful tool for FCD characterisation. 2. FA and MD discriminated between FCD and contralateral brain parenchyma (CBP). 3. Status epilepticus increased the FA difference values between FCD and CBP. 4.
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O’Gorman Tuura, Georgia Ramantani   +5 more
doaj   +1 more source

Cortical Malformations: Lessons in Human Brain Development

Frontiers in Cellular Neuroscience, 2020
Creating a functional cerebral cortex requires a series of complex and well-coordinated developmental steps. These steps have evolved across species with the emergence of cortical gyrification and coincided with more complex behaviors.
Lakshmi Subramanian, Maria Elisa Calcagnotto, Maria Elisa Calcagnotto, Maria Elisa Calcagnotto, Mercedes F. Paredes, Mercedes F. Paredes, Mercedes F. Paredes   +6 more
doaj   +1 more source