Malformations of cortical development Malformações do desenvolvimento cortical [PDF]
Arquivos de Neuro-Psiquiatria, 2009 Malformations of cortical development (MCD) have been increasingly identified. The purpose of this presentation is to review the current knowledge of the MCD. Before we address this issue, we will briefly present a review of cortical development.
Marilisa M. Guerreiro
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Malformations of cortical development. [PDF]
Ann Neurol, 2016 The malformations of cortical development (MCD) result from disruptions in the complex process of human brain cortex formation and are an important cause of epilepsy and developmental delay [1].
Desikan RS, Barkovich AJ.
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Using cortical organoids to understand the pathogenesis of malformations of cortical development [PDF]
Frontiers in NeuroscienceMalformations of cortical development encompass a broad range of disorders associated with abnormalities in corticogenesis. Widespread abnormalities in neuronal formation or migration can lead to small head size or microcephaly with disorganized ...
Kellen D. Winden +2 more
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Why Malformations of Cortical Development Cause Epilepsy [PDF]
Frontiers in Neuroscience, 2019 Malformations of cortical development (MCDs), a complex family of rare disorders, result from alterations of one or combined developmental steps, including progenitors proliferation, neuronal migration and differentiation.
Alfonso Represa
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Malformations of cortical development and epilepsy. [PDF]
Cold Spring Harb Perspect Med, 2015 Malformations of cortical development (MCDs) are an important cause of epilepsy and an extremely interesting group of disorders from the perspective of brain development and its perturbations. Many new MCDs have been described in recent years as a result of improvements in imaging, genetic testing, and understanding of the effects of mutations on the ...
Barkovich AJ, Dobyns WB, Guerrini R.
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Malformations of cortical development: Fetal imaging and genetics [PDF]
Molecular Genetics & Genomic MedicineBackground Malformations of cortical development (MCD) are a group of congenital disorders characterized by structural abnormalities in the brain cortex.
Lin‐Lin Wang +10 more
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Malformations of cortical development: genetic mechanisms and diagnostic approach [PDF]
Korean Journal of Pediatrics, 2017 Malformations of cortical development are rare congenital anomalies of the cerebral cortex, wherein patients present with intractable epilepsy and various degrees of developmental delay. Cases show a spectrum of anomalous cortical formations with diverse
Jeehun Lee
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The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development [PDF]
BMC MedicineBackground Malformations of cortical development (MCD) are a group of congenital brain malformation disorders commonly associated with pharmacoresistant epilepsy (PRE). While studies often focus on surgery outcomes, the pharmacological treatment is still
Pu Miao +10 more
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Malformations of cortical development: Embryology and epilepsy. [PDF]
EpilepsiaOne in seven patients with focal epilepsy has a malformation of cortical development (MCD) as underlying cause. Understanding normal cortical development combined with knowledge of where, when, and what goes wrong in different types of MCD provides insight into the mechanisms of epileptogenesis.
Hoeberigs MC +2 more
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Language Dominance in Patients With Malformations of Cortical Development and Epilepsy [PDF]
Frontiers in Neurology, 2019 Background: Language function may be reorganized in patients with malformations of cortical development (MCD). This prospective cohort study aimed in assessing language dominance in a large group of patients with MCD and epilepsy using functional MRI ...
Giorgi Kuchukhidze +17 more
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