Results 161 to 170 of about 2,484 (216)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Chemical degradation of isotopic succinic and malic acids.

Journal of the American Chemical Society, 1948
Benson, A.A., Bassham, J.A.
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Preservation of lipids with malic acid

Journal of the American Oil Chemists' Society, 1970
AbstractThis paper deals with an evaluation of malic acid in a number of different lipids of animal and vegetable origin under comparable conditions. An Active Oxygen Method was used, with citric acid as the standard of comparison. In most cases, the performance of the acids was determined in the presence and absence of added iron salts and ...
S E, Berger, C V, Krolewski, L C, Wizemann   +2 more
openaire   +2 more sources

Excretion of l-malic acid in the chicken

American Journal of Physiology-Legacy Content, 1960
The mechanism of excretion of malic acid has been studied during infusion of sodium salts of l-malic acid, succinic acid and malonic acid in the chicken. Infusion of preformed l-malate results in its filtration and reabsorption in the nephron; no renal tubular secretion is seen under these circumstances. However, when succinate is infused in the renal
P, VISHWAKARMA, W D, LOTSPEICH
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The Benzoylation of Malic Acid

1925
No abstract.
openaire   +1 more source

Comparative study of carboxylic acid adsorption on calcite: l-malic acid, d-malic acid and succinic acid

Carbonates and Evaporites, 2018
Succinic acid and l-malic acid are known to affect calcite dissolution/crystallization due to their tendency to adsorb on calcite’s surface. Taking into account the structural similarity among succinic acid, l-malic acid, and d-malic acid, a comparative study of their adsorption behavior on calcite was investigated for clarifying their adsorption ...
Zhenxuan Li, Jiangtian Xiao, Lidong Huang, Defu Xu, Dagang Liu, Xiaowen Sun, Luji Yu, Hongsheng Wu   +7 more
openaire   +1 more source

D-Malic acid production from DL-malic acid by microbial assimilation of L-malic acd: Screening of microrganism

Biotechnology Techniques, 1993
Several microorganisms including Pseudomonas fluorescens, Ps. putida, Bacillus megaterium, Acinetobacter Iwofii, Klebsiella oxytoca, K. pneumoniae, Serratia rubidaea and Bulleromyces albus were selected for the ability to assimilate specifically L-malic acid. D-Malic acid with high optical purity (>90%) was obtained from the culture broth.
Masayo Miyama, Kiyoshi Nakayama
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Structures of l-lactic acid chloralide, d-malic acid chloralide and l-malic acid chloralide

Journal of Molecular Structure, 1997
Abstract The crystal and molecular structures of l -lactic acid chloralide and l -malic acid chloralide have been determined by X-ray diffraction methods. l -lactic acid chloralide crystallises in the monoclinic space group, p2 1 , a =7.650 (3), b =5.856 (2), c =9.808 (4) ′, β =99.64 (3)°, Z =2.
Z. Pang, W., H. Huang, H., L. Koh, L.
openaire   +1 more source