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Oxidative stress and cardiovascular risk related to urinary metal(loid) levels in a pediatric population. [PDF]
Ortega-Romero M +11 more
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Cleavage and Oligomerization of Malondialdehyde
Tetrahedron, 1993Abstract Malondialdehyde (MDA) slowly self-condensates in aqueous solution at pH 4.5–6 and room temperature yielding (E)-(3′-oxo-1′-propenyl)malondialdehyde and 2,4-dihydroxymethylene-3-(2′-oxoethyl)glutaraldehyde. The latter compound exists in solution in equilibrium with 4-(1,3-dioxopropan-2-yl)-5-formyl-2-hydroxy-3,4-dihydro-2H-pyran, the trans ...
JOSÉ M Lassaletta, Inés Maya
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Methyl malondialdehyde as an internal standard for the determination of malondialdehyde
Journal of Chromatography B: Biomedical Sciences and Applications, 2001Methyl malondialdehyde (Me-MDA) is suggested as an internal standard for the determination of the lipid peroxidation product, malondialdehyde (MDA). A procedure for synthesising the Me-MDA sodium salt is described in detail. The purity and identity of the synthesised Me-MDA have been confirmed using nuclear magnetic resonance and UV spectroscopy, and ...
K, Claeson, G, Thorsén, B, Karlberg
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Malondialdehyde measurement in urine
Journal of Chromatography B: Biomedical Sciences and Applications, 1994Malondialdehyde (MDA) is an end product of lipid peroxidation and is a frequently measured index of these processes. The thiobarbituric acid (TBA) test is commonly used to measured MDA, but its specificity is questionable due to the presence of interfering chromogens.
M, Guichardant +4 more
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An indo investigation of the structure and bonding in malondialdehyde and lithium malondialdehyde
Journal of Molecular Structure, 1975Abstract The geometries of the enol forms of malondialdehyde and its lithium analog have been investigated using the INDO MO method in its original parametrization. The former molecule is predicted to have a planar, symmetric structure nearly identical with that of acetylacetone.
F.J. Marsh, B.G. Thomas, M.S. Gordon
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Malondialdehyde Derivatives in Urine
1988Malondialdehyde (MDA) excretion in rat urine is responsive to peroxidation of dietary lipids and to factors which increase lipid peroxidation in vivo: vitamin E deficiency and administration of iron, CCI4 or adriamycin. Urinary MDA is also increased by administration of the lipolytic hormones ACTH and epinephrine and by fasting, particularly when the ...
H H, Draper, M, Hadley
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Unequivocal demonstration that malondialdehyde is a mutagen
Carcinogenesis, 1983Malondialdehyde (MDA), a product of lipid peroxidation and prostaglandin biosynthesis, has been reported to be mutagenic and carcinogenic. Recent evidence suggests, however, that strongly mutagenic impurities are generated during the preparation of MDA that may contribute to the observed biological activity.
A K, Basu, L J, Marnett
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Effect of malondialdehyde on nitrosamine formation
Food and Cosmetics Toxicology, 1980Abstract Several aldehydes associated with foodstuffs were investigated for their effect on the formation of N-nitrosodimethylamine and N-nitrosodiethylamine. Whereas glucose, furfural, benzaldehyde and glyoxal had little influence on nitrosamine formation, malondialdehyde, which can be derived from lipids by peroxidation, greatly influenced the ...
T, Kurechi, K, Kikugawa, M, Ozawa
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Ascorbate and malondialdehyde in stroke patients
Irish Journal of Medical Science, 1994It is believed that free radical formation and subsequent oxidative damage in the form of lipid peroxidation may be a factor in the cerebral damage secondary to the ischaemia of a cerebrovascular accident (CVA). Total serum ascorbate and malondialdehyde (MDA) were measured in 45 patients with CVA on the day of admission to hospital (Time 0) and 48 ...
P C, Sharpe, C, Mulholland, T, Trinick
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