Results 221 to 230 of about 138,770 (255)
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The Analyst, 2011
Malondialdehyde (MDA) has become a well-established biomarker for oxidative stress. The most commonly used way to determine urinary MDA levels is the thiobarbituric acid (TBA) assay, which suffers from several drawbacks. In this manuscript, we describe a novel derivatization strategy for the highly sensitive and selective fluorescence-based ...
Giera, M. +6 more
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Malondialdehyde (MDA) has become a well-established biomarker for oxidative stress. The most commonly used way to determine urinary MDA levels is the thiobarbituric acid (TBA) assay, which suffers from several drawbacks. In this manuscript, we describe a novel derivatization strategy for the highly sensitive and selective fluorescence-based ...
Giera, M. +6 more
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Unique promotion of erythrophagocytosis by malondialdehyde
American Journal of Hematology, 1988AbstractModification of the normal erythrocyte membrane by reagent malondialdehyde (MDA) promotes phagocytosis of red blood cells by human macrophages, a phenomenon previously shown to involve both IgG‐dependent and IgG‐independent mechanisms and to be demonstrable even at micromolar MDA concentrations.
R P, Hebbel, W J, Miller
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Distribution and oxidation of malondialdehyde in mice
Prostaglandins, 1985The in vivo metabolism of malondialdehyde (MDA) by male and female Swiss mice was investigated. Distribution of an i.p. dose of MDA is rapid and uniform throughout the body. Conversion of 14C-labeled MDA to CO2 is complete 4 hours after an i.p. dose of 5 mumol to 200 mumol with no signs of short term toxicity.
L J, Marnett +4 more
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Malondialdehyde, modified lipoproteins, and atherosclerosis
European Heart Journal, 1990It is likely that identification of the mechanisms releasing malondialdehyde and other peroxidative decomposition products in the arterial wall will provide new insights into the sequence of biochemical and cellular events in the pathogenesis of atherosclerosis and ultimately may lead to development of strategies for the intervention and reduction of ...
M E, Haberland, D, Fong, L, Cheng
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Proinflammatory effects of malondialdehyde in lymphocytes
Journal of Leukocyte Biology, 2012Abstract MDA changed cytokine/chemokines mRNA profiles in lymphocytes; increased cytokines expression is via oxidative stress, p38MAPK, and PKC pathways. Diabetes is an inflammatory disease promoted by alterations in immune cell function.
Somasundaram, Raghavan +2 more
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Malondialdehyde formation in stored plasma
Biochemical and Biophysical Research Communications, 1980Summary The formation of malondialdehyde in plasma during storage was used as an indicator of lipid peroxidation. Malondialdehyde concentrations were measured in plasma stored at 4°C in the presence of various preservative reagents. A rapid rate of formation of malondialdehyde (15.0 ± 14.0 nmol/dl/week) was observed in control plasma preserved with ...
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Electronic spectroscopy of malondialdehyde
Chemical Physics Letters, 1976Abstract The electronic absorption spectra of malondialdehyde in vapor and solutionphases and derived monoanion in solution are presented. Comparison of CNDO/s-CI computations with experiment allows two singlet—singlet transitions at λ ⩾ 1800 A to be assigned within the G 4 molecular symmetry group description of the planar non-rigid neutral ...
Carl J. Seliskar, Richard E. Hoffman
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Malondialdehyde epitopes as mediators of sterile inflammation
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017Enhanced lipid peroxidation occurs during oxidative stress and results in the generation of lipid peroxidation end products such as malondialdehyde (MDA), which can attach to autologous biomolecules, thereby generating neo-self epitopes capable of inducing potentially undesired biological responses. Therefore, the immune system has developed mechanisms
Clara J, Busch, Christoph J, Binder
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Malondialdehyde Contents in Infant Milk Formulas
Journal of Agricultural and Food Chemistry, 2004Malondialdehyde (MDA) levels in infant milk formulas have been monitored by using an aqueous acid extraction method combined with the thiobarbituric acid method (TBA-test). Vegetable oils, with a remarkable content of polyunsaturated fatty acids (PUFA) are used to enrich the infant milk formulas. As PUFA are more susceptible to autoxidation, it becomes
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Malondialdehyde in Biological Systems
2019Malondialdehyde (MDA) is one of several decomposition products of lipid peroxides formed in fats and oils, in food, and in the tissues. It is the most extensively investigated of these products because of its reactivity with a range of biological macromolecules and its association with the pathophysiology of a number of disease states.
H. H. Draper +3 more
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