Results 91 to 100 of about 99,209 (245)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Relationships among malondialdehyde, milk compositions, and somatic cell count in milk from bulk tank [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2010
The goals of this study were to identify associations of malondialdehyde (MDA) with milk compositions and somaticcell counts (SCC) in milk from bulk tanks.
Witaya Suriyasathaporn, Usanee Vinitketkumnuen, Teera Chewonarin   +2 more
doaj  

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Cholesterol and Malondialdehyde Contents of Broiler-Chicken Meat Supplemented with Indigofera zolingeriana Top Leaf Meal

Media Peternakan, 2015
This research aimed to increase functional value of broiler-chicken meat containing high antioxidant and low cholesterol through substitution of soybean meal (SBM) with Indigofera zollingeriana top leaf meal (ILM). The experiment used 160 day old broiler
M. A. Santi , Sumiati, L. Abdullah
doaj   +1 more source

Vitamin C supplementation lowers advanced glycation end products (AGEs) and malondialdehyde (MDA) in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. [PDF]

Food Sci Nutr, 2023
Rabizadeh S, Heidari F, Karimi R, Rajab A, Rahimi-Dehgolan S, Yadegar A, Mohammadi F, Mirmiranpour H, Esteghamati A, Nakhjavani M.   +9 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

A Study on Brown Seaweed Therapy ( Sargassum sp.) toward MDA Levels and Histological Improvement on Rat Foot Suffering Rheumatoid Arthritis

Journal of Pure and Applied Chemistry Research, 2013
Rheumatoid arthritis (AR), an autoimun disease, is characterized by the inflammation in the joint area caused an excessive of free radicals. An excessive of free radicals in the body cause oxidative stress, that increasing levels of malondialdehyde (MDA)
Fauziah Fauziah, Aulanni'am Aulanni'am, Chanif Mahdi   +2 more
doaj  

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Serum malondialdehyde concentration as a measure of oxygen free radical damage in preterm infants

The Turkish Journal of Pediatrics, 1998
Lipid peroxidation was measured in 35 preterm infants by determining serum malondialdehyde (MDA) levels during the fist week of life. Serum concentrations of MDA were measured at one hour, 24 hours, 48 hours and one week of age.
S Yiğit, M Yurdakök, K Kilinç, O Oran, G Erdem, G Tekinalp   +5 more
doaj  

The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study. [PDF]

Health Promot Perspect, 2021
Vaghef-Mehrabani E, Izadi A, Ebrahimi-Mameghani M.   +2 more
europepmc   +1 more source