Results 61 to 70 of about 34,836 (260)

Prognostic impact of MALs and potential immunotherapy targets in uveal melanoma

Pediatric Discovery
Uveal melanoma (UM) is the most common primary ocular malignancy in adults, and the 5‐year disease‐related mortality rate is 30%. MAL proteolipid family (MALs), including T‐cell differentiation protein (MAL), T‐cell differentiation protein 2 (MAL2), and ...
Jing Yang, Zhou Fu, Qin Xiang
doaj   +1 more source

Ecdysone signaling regulates specification of neurons with a male-specific neurite in Drosophila

Biology Open, 2018
Some mAL neurons in the male brain form the ipsilateral neurite (ILN[+]) in a manner dependent on FruBM, a male-specific transcription factor. FruBM represses robo1 transcription, allowing the ILN to form.
Binglong Zhang, Kosei Sato, Daisuke Yamamoto   +2 more
doaj   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Management of median arcuate ligament syndrome

Journal of Vascular Surgery Cases and Innovative Techniques
Median arcuate ligament syndrome (MALS) is a diagnostically challenging vascular compression disorder resulting from external compression of the celiac artery by the diaphragmatic crura.
Mohit K. Manchella, BS, Vincent Wu, MD, Anahita Dua, MBChB, MD, MS, MBA, FACS   +2 more
doaj   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Assessment of Transserosal Microcirculation with Visible Light Spectroscopy and Laser Doppler Flowmetry in Patients with Median Arcuate Ligament Syndrome and Chronic Mesenteric Ischemia

Vascular Health and Risk Management
Gorm von Gohren Edwin,1,2 Berit Kristine Bendixen Skraastad,1,2 Jonny Hisdal,1,2 Torbjørn Wisløff,2,3 Jon Otto Sundhagen,1 Syed Sajid Hussain Kazmi1,2 1Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University ...
Edwin GVG, Skraastad BKB, Hisdal J, Wisløff T, Sundhagen JO, Kazmi SSH   +5 more
doaj  

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Hydraulicity in Organic Polymers Enabled by Hydrophobization Upon Water‐Triggered Curing of Hydrophilic Chains

Angewandte Chemie, EarlyView.
Cement‐mimetic hydraulicity is realized in an organic polymer through a counterintuitive reaction in which a hydrophilic linear polymer reacts with water to undergo hydrophobization during curing via silatrane sol–gel chemistry. This polarity‐inverting curing process turns a water‐plasticized putty into a water‐tolerant rigid material, enabling ...
Rei Tokumitsu, Shio Uebo, Akira Takahashi, Hideyuki Otsuka   +3 more
wiley   +2 more sources

THE PATHOLOGY, ETIOLOGY AND TREATMENT OF PETIT MAL AND GRAND MAL. [PDF]

JAMA: The Journal of the American Medical Association, 1896
Both of these forms of epilepsy belong with tetanus and hydrophobia to diseases of the nervous system, petit mal, the congenital or mild form occurring in childhood, grand mal, the inherited and acquired, the result of traumatism and developed during some period of adult life.
openaire   +2 more sources

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source