Results 101 to 110 of about 63,932 (259)

A paper‐based bi‐enzymatic sensor for chemiresistive glucose detection

open access: yesVIEW, EarlyView.
This paper presents the development of a paper‐based glucose sensor utilizing poly(3,4‐ethylene‐dioxythiophene) polystyrene sulfonate (PEDOT:PSS) and a bi‐enzymatic system with Horseradish Peroxidase (HRP) and Glucose Oxidase (GOx). The chemiresistive sensor is optimized for detecting glucose in biofluids such as saliva, requiring only 40 µL of sample ...
Riccardo Zulli   +7 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

open access: yesInsect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li   +5 more
wiley   +1 more source

Development and characterisation of a fully recombinant competition ELISA for the diagnosis of foot‐and‐mouth disease virus infection

open access: yesAustralian Veterinary Journal, EarlyView.
Infection of livestock by foot‐and‐mouth disease (FMD) virus (FMDV) has serious economic implications due to productivity losses and trade restrictions. In countries that are free from foot and mouth disease, the World Organisation for Animal Health (WOAH) provides two proof of freedom from disease status categories; namely, FMD‐free without using ...
S Ye   +7 more
wiley   +1 more source

Structure‐based discovery of thiamine uptake inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel   +2 more
wiley   +1 more source

Studies of the membrane‐bound flavocytochrome MsrQ flavin mononucleotide (FMN)‐binding site reveal an unexpected ubiquinone cofactor

open access: yesThe FEBS Journal, EarlyView.
The membrane‐bound heme flavoprotein MsrQ is the specific electron donor for the periplasmic methionine sulfoxide reductase MsrP. Analysis of its flavin environment revealed that ubiquinone (UQ) is a cofactor for MsrQ. However, redox studies demonstrate that UQ cannot function as an electron donor for the MsrPQ system.
Philippe Carpentier   +9 more
wiley   +1 more source

Clinical and biochemical features of some intravenous iron complexes

open access: yesОнкогематология, 2014
Most anemia cases associated with iron deficiency. There are various therapeutic approaches to compensate iron deficiency. In some cases,a rapid restore of body iron is required, which is only possible with intravenous administration.
S. Yu. Abashin   +3 more
doaj  

TaIRE1‐mediated unconventional splicing of the TabZIP60 mRNA and the miR172 precursor regulates heat stress tolerance in wheat

open access: yesJournal of Integrative Plant Biology, EarlyView.
In wheat, INOSITOL‐REQUIRING ENZYME 1 (IRE1) helps plants cope with heat stress by regulating unconventional splicing of the mRNA encoding the bZIP transcription factor TabZIP60, which activates heat‐responsive genes, and cleavage of the precursor of the microRNA miR172 during heat stress.
Haoran Li   +15 more
wiley   +1 more source

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