Results 51 to 60 of about 14,055 (248)

Editorial

Revista Brasileira de Cancerologia, 2023
O editorial apresenta os anais do Seminário Nacional sobre Controle do Câncer Cérvico-Uterino e de Mama, realizado entre 29 e 31 de janeiro de 1985, no Instituto Nacional de Câncer, promovido pela CNCC/INCA, PAISM e Organização Panamericana da Saúde ...
Antonio Ivo de Carvalho, Dóra Chor de Souza Ribeiro, Eduardo Faerstein, Estela Maria Leão de Aquino   +3 more
doaj  

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Estratégia dos cuidadores informais no domicílio a doentes com cancro do pulmão em fase terminal

Onco.News, 2012
No contexto dos cuidados às pessoas em fim de vida é premente solucionar problemas e adoptar estratégias de resolução das dificuldades e necessidades dos mesmos e dos cuidadores informais.
Emília Rito
doaj   +1 more source

Gaps in Knowledge and Understanding of Patients With Metastatic Breast Cancer in Mexico

Cancer Control, 2020
There is paucity of data regarding the knowledge and understanding of patients with metastatic breast cancer (MBC) about their disease stage and treatment goals.
Cynthia Villarreal-Garza MD, DSc, Fernanda Mesa-Chavez MD, Edna Anakarenn Lopez-Martinez MD, Alan Fonseca MD, Claudia Pineda MD, Fernanda Rivera MD, Marisol Garcia-Garcia MD, Sylvia de la Rosa-Pacheco MSc, MD, Alejandro Mohar MD, DSc, Corrine Ellsworth-Beaumont MFA, PhD, Alejandra Platas MSc   +10 more
doaj   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Employment Status Among Brazilian Women With Estrogen Receptor‐Positive Nonmetastatic Breast Cancer

Cancer Medicine
Background Employment is a critical determinant of quality of life, social reintegration, and financial stability for breast cancer survivors. International studies have shown that return‐to‐work (RTW) rates vary widely, ranging from 27% to over 80 ...
Daniele Assad‐Suzuki, Luciana Castro Garcia Landeiro, Danielle Laperche‐Santos, Heloisa Resende, Fernanda Cesar Moura, Sulene Cunha Sousa Oliveira, Andrea Kazumi Shimada, Renata Arakelian, Anna Luiza Zapalowski Galvão, Bruno Santos Wance deSouza, Amanda Guimarães Castro Custódio, Monalisa Ceciliana Freitas Moreira deAndrade, Yuri Cardoso Rodrigues Beckedorff Bittencourt, Maria Cristina Figueroa Magalhães, Cristiano de Pádua Souza, Carlos Eduardo Paiva, Poliana Albuquerque Signorini, Ariane Vieira Carvalho, Daniela Jessica Pereira, Laura Cereser Albaneze, Angélica Nogueira‐Rodrigues, Daniela Dornelles Rosa, Romualdo Barroso‐Sousa   +22 more
doaj   +1 more source

Rendimiento de una herramienta de inteligencia artificial en biopsias percutáneas de mama

Revista Chilena de Radiología
Introducción: El uso de herramientas de inteligencia artificial (IA) en ecografía mamaria ha mostrado un aumento en la exactitud diagnóstica del cáncer de mama.
Paulina Neira-Vallejos, María C. Vial, Carolina Behnke, Marcelo Poblete-Becker, M. Rosario van Wersch, Emilia Santelices   +5 more
doaj   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source