Results 41 to 50 of about 165,269 (210)

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin, Yulong Yin   +9 more
doaj   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells

Tumor Biology, 2017
Recently, statins have been demonstrated to improve cancer-related mortality or prognosis in patients of various cancers. However, the details of the apoptosis-inducing mechanisms remain unknown.
Daichiro Fujiwara, Masanobu Tsubaki, Tomoya Takeda, Yoshika Tomonari, Yu-ichi Koumoto, Katsuhiko Sakaguchi, Shozo Nishida   +6 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

Topical rapamycin (sirolimus) for facial angiofibromas

Indian Dermatology Online Journal, 2013
Rapamycin (sirolimus) is a fungal fermentation product that inhibits the proper functioning of a serine/threonine protein kinase in mammalian cells eponymously named mammalian target of rapamycin, or mTOR.
Bhushan Madke
doaj   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

Cardiovascular Diabetology, 2012
Diabetes mellitus currently affects more than 170 million individuals worldwide and is expected to afflict another 200 million individuals in the next 30 years.
Chong Zhao, Maiese Kenneth
doaj   +1 more source

Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Frontiers in Pharmacology, 2020
Depression is the leading cause of disability worldwide, which necessitates novel therapeutics and biomarkers to approach treatment of this neuropsychiatric disorder.
Jenessa N. Johnston, Jonathan S. Thacker, Charissa Desjardins, Brian D. Kulyk, Raquel Romay-Tallon, Lisa E. Kalynchuk, Hector J. Caruncho   +6 more
doaj   +1 more source