Results 31 to 40 of about 71,975 (282)

Weight gain increases human aromatase expression in mammary gland [PDF]

Molecular and Cellular Endocrinology, 2012
Adulthood weight gain predicts estrogen receptor-positive breast cancer. Because local estrogen excess in the breast likely contributes to cancer development, and aromatase is the key enzyme in estrogen biosynthesis, we investigated the role of local aromatase expression in weight gain-associated breast cancer risk in a humanized aromatase (Arom(hum ...
Dong, Chen, Hong, Zhao, John S, Coon, Masanori, Ono, Elizabeth K, Pearson, Serdar E, Bulun   +5 more
openaire   +2 more sources

Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (tree shrew).

PLoS ONE, 2020
Mammary gland cancer is the most common cancer occurring in women globally. Incidences of this cancer in Japan are on the increase. Annually, more than 70,000 new cases are recorded in Japan and about 1.7 million in the world.
Chi Hai-Ying, Yuki Tanaka, Tatsuro Hifumi, Koichiro Shoji, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara   +15 more
doaj   +1 more source

A secretory kinase complex regulates extracellular protein phosphorylation. [PDF]

, 2015
Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored.
Cui, Jixin, Dixon, Jack E, Rahdar, Meghdad, Tagliabracci, Vincent S, Wen, Jianzhong, Xiao, Junyu   +5 more
core   +2 more sources

Over-expression of mammaglobin-B in canine mammary tumors

BMC Veterinary Research, 2018
Background Mammaglobin, a member of secretoglobin family has been recognized as a breast cancer associated protein. Though the exact function of the protein is not fully known, its expression has been reported to be upregulated in human breast cancer.We ...
Mamta Pandey, B. V. Sunil Kumar, Kuldip Gupta, Ram Saran Sethi, Ashwani Kumar, Ramneek Verma   +5 more
doaj   +1 more source

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. [PDF]

, 2016
Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer.
Anderton, Brittany, Balakrishnan, Sanjeev, Camarda, Roman, Eyob, Henok, Goga, Andrei, Kajimura, Shingo, Kohnz, Rebecca A, Krings, Gregor, Mahieu, Celine, Nomura, Daniel K, Tward, Aaron, Zhou, Alicia Y   +11 more
core   +1 more source

Precursors of hexoneogenesis within the human mammary gland

American Journal of Physiology-Endocrinology and Metabolism, 2015
The human mammary gland is capable of de novo synthesis of glucose and galactose (hexoneogenesis); however, the carbon source is incompletely understood. In this study, we investigated the role of acetate, glutamine, lactate and glycerol as potential carbon sources for hexoneogenesis.
Mahmoud A, Mohammad, Patricia, Maningat, Agneta L, Sunehag, Morey W, Haymond   +3 more
openaire   +3 more sources

Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer

Frontiers in Oncology, 2019
Melatonin has numerous anti-cancer properties reported to influence cancer initiation, promotion, and metastasis. With the need for effective hormone therapies (HT) to treat menopausal symptoms without increasing breast cancer risk, co-administration of ...
Balasunder R. Dodda, Corry D. Bondi, Mahmud Hasan, William P. Clafshenkel, Katie M. Gallagher, Mary P. Kotlarczyk, Shalini Sethi, Ethan Buszko, Jean J. Latimer, J. Mark Cline, Paula A. Witt-Enderby, Paula A. Witt-Enderby, Vicki L. Davis   +12 more
doaj   +1 more source

Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. [PDF]

, 2019
Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands.
Aaron Hardin, Andersen, Bao, Besemer, Bickhart, Blanchette, Bolger, Bonwitt, Booker, Bourque, Camacho, Capra, Chapman, Chen, Chikhi, Chu, Colangelo, Dewey, Dierckxsens, Eblaghie, Grabherr, Hayssen, Heinz, Helfrich, Holloway, Holt, Jiang, Kannan, Kiełbasa, Kim, Kimberly A Nevonen, Kolmogorov, Korf, Krueger, Lecompte, Li, Li, Lok, Lowe, Lucia Carbone, MacManes, McLean, Modlin, Nadav Ahituv, Nagy, Nilsson, Närhi, Pennacchio, Pertea, Pimentel, Pollard, Sands, Schep, Scott, Siepel, Siepel, Simão, Smit, Snell, Song, Stanke, UniProt Consortium, Van der Auwera, Veltmaat, Veltmaat, Walter L Eckalbar   +65 more
core   +1 more source

Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells. [PDF]

PLoS ONE, 2010
BACKGROUND: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices.
Eugenio Martignani, Peter Eirew, Paolo Accornero, Connie J Eaves, Mario Baratta   +4 more
doaj   +1 more source

High-affinity folate binding in human mammary gland

Bioscience Reports, 1993
High-affinity 3H-folate binding in Triton X-100 solubilized human mammary gland tissue displayed characteristics, e.g. apparent positive cooperativity and increasing affinity with decreasing concentration of folate binding protein, shown to be typical of specific folate binding. Radioligand dissociation was slow at pH 7.4. A major fraction of the bound
J, Holm, S I, Hansen, M, Høier-Madsen
openaire   +2 more sources