Results 51 to 60 of about 42,336 (264)

Preliminary Study of Yucatan Porcine Breast Morphology: Identifying Basic Differences and Similarities for Surgical Model Applications

Surgeries
Background/Objectives: The porcine mammary anatomy is poorly characterized, and structures are difficult to differentiate macroscopically, unlike human mammary tissue.
Darcy H. Gagne, Catherine C. Steele, John Keating, Kasia Bradbury, Amit Badhwar, Sakib F. Elahi   +5 more
doaj   +1 more source

CXCL12γ induces human prostate and mammary gland development

The Prostate, 2020
AbstractBackgroundEpithelial stem cells (ESCs) demonstrate a capacity to maintain normal tissues homeostasis and ESCs with a deregulated behavior can contribute to cancer development. The ability to reprogram normal tissue epithelial cells into prostate or mammary stem‐like cells holds great promise to help understand cell of origin and lineage ...
Younghun Jung, Jin Koo Kim, Eunsohl Lee, Frank C. Cackowski, Ann M. Decker, Paul H. Krebsbach, Russell S. Taichman   +6 more
openaire   +5 more sources

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Identification of Steroid Sulfate Transport Processes in the Human Mammary Gland [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS) constitutes a major adrenal precursor.
Pizzagalli, F., Varga, Z., Huber, R. D., Folkers, G., Meier, P. J., St-Pierre, M. V.   +5 more
openaire   +4 more sources

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.

PLoS ONE, 2013
Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is independent of estrogen receptor alpha (ERα) status and is frequently associated with overexpression of
Myles C Hodgson, Garrett Vanostran, Sarah Alghamdi, Robert J Poppiti, Alexander I Agoulnik, Irina U Agoulnik   +5 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Human γ‐interferon expression in the mammary gland of transgenic mice [PDF]

FEBS Letters, 1993
Transgenic mice carrying a hybrid gene consisting of ovine β‐lactoglobulin gene sequences and human γ‐interferon (hIFN‐g) cDNA were produced. hIFN‐g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN‐g in the milk was estimated as being ca. 1800 IU/ml. The hIFN‐g ability to express in
Dobrovolsky, V.N., Lagutin, O.V., Vinogradova, T.V., Frolova, I.S., Kuznetsov, V.P., Larionov, O.A.   +5 more
openaire   +2 more sources

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source