Results 41 to 50 of about 43,371 (303)

Pubertal low dose exposure to benzophenone-3 (BP-3) alters murine mammary stem cell functions

Ecotoxicology and Environmental Safety
Benzophenone-3 (BP-3) is an organic UV filter that is widely used in personal care products and has been indicated to have negative impacts on the environment and human health.
Hui Gao, Xintong Yang, Pengge Pan, Xueli Liu, Yan Ma, Yadan Chen, Yunxin Liu, Yaqi Sun, Sinan Cao, Yuan Tian, Yanzhou Yang   +10 more
doaj   +1 more source

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

BMC Cancer, 2008
Background Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5) promoter has previously been shown to induce epidermal hyperplasia, hair follicle anomalies
Thames Howard D, Sahin Aysegul, McArthur Mark J, Kiguchi Kaoru, Yan Leqin, Arantes Stacey, Wang Aijin, Aldaz C Marcelo, MacLeod Michael C   +8 more
doaj   +1 more source

Reprogramming Human Cancer Cells in the Mouse Mammary Gland [PDF]

Cancer Research, 2010
Abstract The tissue microenvironment directs stem/progenitor cell behavior. Cancer cells are also influenced by the microenvironment. It has been shown that, when placed into blastocysts, cancer cells respond to embryonic cues and differentiate according to the tissue type encountered during ontological development.
Karen M, Bussard, Corinne A, Boulanger, Brian W, Booth, Robert D, Bruno, Gilbert H, Smith   +4 more
openaire   +2 more sources

Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report

Diagnostic Pathology, 2010
A rare case of an apocrine tumor in the male perineal region is reported. A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male. The cystic lesion, measuring 3.5 × 5.0 cm in size, was lined by columnar
Yoshioka Takako, Umekita Yoshihisa, Tanimoto Akihide, Hatanaka Kazuhito, Kanekura Takuro   +4 more
doaj   +1 more source

Prions in Milk from Ewes Incubating Natural Scrapie [PDF]

, 2008
Since prion infectivity had never been reported in milk, dairy products originating from transmissible spongiform encephalopathy (TSE)-affected ruminant flocks currently enter unrestricted into the animal and human food chain.
Bergonier Dominique, Fabien Corbière, Lacroux, Caroline, Cassard Hervé, Grassi, Jacques, Andréoletti Olivier, Torffin Moldal, Sylvie L. Benestad, Schelcher, Francois, F., Lugan, Séverine, S., Costes, Pierrette, Benestad Sylvie L., Simmons Hugh, Sylvie L Benestad, Nathalie Morel, Lantier, Frédéric, F., Simon Stéphanie, Lacroux Caroline, Weisbecker, Jean Louis, J. L., Benestad, Sylvie, Hervé Cassard, Bergonier, Dominique, Schelcher, François, Weisbecker, Jean-Louis, Morel, Nathalie, Weisbecker Jean-Louis, Lantier Frederic, Moldal, Torffin, François Schelcher, Stéphanie Simon, Simmons, Hugh, Dominique Bergonier, Morell, Nathalie, Jacques Grassi, Olivier Andréoletti, Schelcher François, Cécile Feraudet-Tarisse, Andréoletti, Olivier, Pierrette Costes, Cassard, Hervé, H., Corbière Fabien, Caroline Lacroux, Maillet, Séverinne, Mathey, Jacinthe, Jean-Louis Weisbecker, Mathey Jacinthe, Hugh Simmons, Cassard, Hervé, Corbière, Fabien, Féraudet-Tarisse, Cécile, Jacinthe Mathey, Feraudet-Tarisse Cécile, Frederic Lantier, Simon, Stéphanie, Séverine Lugan, Séverine Maillet, Morel Nathalie, Costes Pierrette, Costes, Pierrette, P., Lantier, Frédéric, Grassi Jacques, Benestad, Sylvie L, Lugan Séverine, Maillet, Séverine, Moldal Torffin, Lugan, Sévérine, Féraudet, Cécile, Lacroux, Caroline, C., Maillet Séverine   +68 more
core   +1 more source

Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2017
Claudin-low breast cancer (CLBC) is a poor prognosis molecular subtype showing stemness and mesenchymal features. We previously discovered that deletion of a Notch signaling modulator, Lunatic Fringe (Lfng), in the mouse mammary gland induced a subset of
Wen-Cheng Chung, Shubing Zhang, Lavanya Challagundla, Yunyun Zhou, Keli Xu   +4 more
doaj   +1 more source

Milk Proteins Are Predigested Within the Human Mammary Gland [PDF]

Journal of Mammary Gland Biology and Neoplasia, 2017
Previous work demonstrates that proteases present in human milk release hundreds of peptides derived from milk proteins. However, the question of whether human milk protein digestion begins within the mammary gland remains incompletely answered. The primary objective of this study was to determine whether proteolytic degradation of human milk proteins ...
Søren D. Nielsen, Robert L. Beverly, David C. Dallas   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Lactoferrin (Lf): Retinoid interactions in the mammary glands of transgenic mice overexpressing human Lf

, 2006
Induction of protein expression in a tissue-specific manner by gene transfer over-expression techniques has been one means to define the function of a protein in a biological paradigm. Studies with retinoid reporter constructs transfected in mammary cell
Friis, Robert R, Baumrucker, Craig R, Blum, Jürg W, Saurer, Susanne, Jungi, Thomas   +4 more
core   +1 more source