Results 41 to 50 of about 71,975 (282)

Examination of Duct Physiology in the Human Mammary Gland [PDF]

PLOS ONE, 2016
Background The human breast comprise several ductal systems, or lobes, which contain a small amount of fluid containing cells, hormones, proteins and metabolites. The complex physiology of these ducts is likely a contributing factor to the development of breast cancer, especially given that the vast majority of breast cancers begin in a single lobular ...
Mills, Dixie, Gomberawalla, Ameer, Gordon, Eva J., Tondre, Julie, Nejad, Mitra, Nguyen, Tinh, Pogoda, Janice M., Rao, Jianyu, Chatterton, Robert, Henning, Susanne, Love, Susan M.   +10 more
openaire   +6 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Reprogramming Human Cancer Cells in the Mouse Mammary Gland [PDF]

Cancer Research, 2010
Abstract The tissue microenvironment directs stem/progenitor cell behavior. Cancer cells are also influenced by the microenvironment. It has been shown that, when placed into blastocysts, cancer cells respond to embryonic cues and differentiate according to the tissue type encountered during ontological development.
Karen M, Bussard, Corinne A, Boulanger, Brian W, Booth, Robert D, Bruno, Gilbert H, Smith   +4 more
openaire   +2 more sources

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

BMC Cancer, 2008
Background Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5) promoter has previously been shown to induce epidermal hyperplasia, hair follicle anomalies
Thames Howard D, Sahin Aysegul, McArthur Mark J, Kiguchi Kaoru, Yan Leqin, Arantes Stacey, Wang Aijin, Aldaz C Marcelo, MacLeod Michael C   +8 more
doaj   +1 more source

Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]

, 2010
Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques, Defrise, Michel, Franken, Philippe R, Guglielmi, Julien, Koulibaly, Malick, Pourcher, Thierry, Vanhove, Christian   +6 more
core   +1 more source

Pubertal low dose exposure to benzophenone-3 (BP-3) alters murine mammary stem cell functions

Ecotoxicology and Environmental Safety
Benzophenone-3 (BP-3) is an organic UV filter that is widely used in personal care products and has been indicated to have negative impacts on the environment and human health.
Hui Gao, Xintong Yang, Pengge Pan, Xueli Liu, Yan Ma, Yadan Chen, Yunxin Liu, Yaqi Sun, Sinan Cao, Yuan Tian, Yanzhou Yang   +10 more
doaj   +1 more source

Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]

, 2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim, Andradas, Clara, Arnold, Norbert, Artola, Marta, Bauer, Maret, Blasco-Benito, Sandra, Bronsert, Peter, Caffarel, María M., Canela, Enric I., Fernández-Piqueras, José, Flores, Juana M., García-Taboada, Elena, Guzmán, Manuel, Hamann, Sigrid, Klapper, Wolfram, Martín-Villar, Ester, McCormick, Peter J., Megías, Diego, Moreno, Estefanía, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Pérez-Gómez, Eduardo, Pérez-Martínez, Manuel, Quintanilla, Miguel, Röcken, Christoph, Soriano, Joaquim, Staebler, Annette, Stickeler, Elmar, Sánchez, Cristina, Villa-Morales, María, Vázquez-Villa, Henar, Wenners, Antonia   +31 more
core   +1 more source

Milk Proteins Are Predigested Within the Human Mammary Gland [PDF]

Journal of Mammary Gland Biology and Neoplasia, 2017
Previous work demonstrates that proteases present in human milk release hundreds of peptides derived from milk proteins. However, the question of whether human milk protein digestion begins within the mammary gland remains incompletely answered. The primary objective of this study was to determine whether proteolytic degradation of human milk proteins ...
Søren D. Nielsen, Robert L. Beverly, David C. Dallas   +2 more
openaire   +2 more sources

Age-associated genes in human mammary gland drive human breast cancer progression [PDF]

Breast Cancer Research, 2020
Abstract Background Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains poorly understood.
Xiang Gu, Bingzhi Wang, Haiyan Zhu, You Zhou, Aaron M. Horning, Tim H-M Huang, Yidong Chen, Peter Houghton, Zhao Lai, Joel E. Michalek, Lu-Zhe Sun   +10 more
openaire   +3 more sources

Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report

Diagnostic Pathology, 2010
A rare case of an apocrine tumor in the male perineal region is reported. A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male. The cystic lesion, measuring 3.5 × 5.0 cm in size, was lined by columnar
Yoshioka Takako, Umekita Yoshihisa, Tanimoto Akihide, Hatanaka Kazuhito, Kanekura Takuro   +4 more
doaj   +1 more source