Results 51 to 60 of about 71,975 (282)

Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2017
Claudin-low breast cancer (CLBC) is a poor prognosis molecular subtype showing stemness and mesenchymal features. We previously discovered that deletion of a Notch signaling modulator, Lunatic Fringe (Lfng), in the mouse mammary gland induced a subset of
Wen-Cheng Chung, Shubing Zhang, Lavanya Challagundla, Yunyun Zhou, Keli Xu   +4 more
doaj   +1 more source

Radiological features of breast benign lesions in patients with hyperprolactinemia [PDF]

Archive of Oncology, 2007
Background: The study was conducted to determine whether prolactin (PRL) influences radiological features of benign breast lesions. Methods: During the 4-year period, we observed 50 patients with nipple discharge: 23 with normal serum prolactin levels ...
Radojković Danijela, Antić Slobodan, Pešić Milica, Radojković Milan, Bašić Dijana, Rađenović-Petković Tatjana   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core  

Developmental expression of claudins in the mammary gland [PDF]

, 2017
Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N ...
Baumgartner, Heidi K., Bitler, Benjamin G., Burns, Valerie, Kobayashi, Ken, Neville, Margaret C., Ramanathan, Palaniappian, Rudolph, Michael C., Stein, Torsten, Webb, Patricia   +8 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +3 more sources

An Insight into Probiotics Bio-Route: Translocation from the Mother’s Gut to the Mammary Gland

Applied Sciences, 2021
Human breast milk (HBM) is unique in its composition as it is adapted to fulfil the newborns’ nutritional requirement and helps in improving the health of newborns. Besides various nutrients, the human milk also contains diverse group of microbiotas. The
Shanmugaprakasham Selvamani, Daniel Joe Dailin, Vijai Kumar Gupta, Mohd Wahid, Ho Chin Keat, Khairun Hani Natasya, Roslinda Abd Malek, Shafiul Haque, R. Z. Sayyed, Bassam Abomoelak, Dalia Sukmawati, Theodoros Varzakas, Hesham Ali El Enshasy   +12 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source