Results 141 to 150 of about 190,981 (166)

CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Synergistic Efficacy of MMH‐I and 5‐Fluorouracil Combination Therapy in CA IX‐Expressing Breast Cancer Models: Pathological and Metabolic Insights. ABSTRACT Carbonic anhydrase IX (CA IX) is overexpressed in many solid tumors, contributing to cancer cell proliferation, survival, invasion, and metastasis.
Sükrü Akmese, Ebru Temiz, Elif Gürel, Ismail Koyuncu, Mustafa Durgun, Muhammet Emin Guldur, Kadir Egi, Beyza Ozerol   +7 more
wiley   +1 more source

Stromal fibroblastic mutant Trp53 promotes mammary tumor development via enhanced secretion of paracrine factors. [PDF]

NPJ Breast Cancer
Liu B, Xiong S, Williams-Villalobo A, Chau G, Qi Y, Chen H, Johnson C, Chachad D, McDaniel J, Su X, El-Naggar AK, Lozano G, Zhang Y.   +12 more
europepmc   +1 more source

The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Microsatellites stability (MSS) colon cancer patients exhibit a significant suppressive immune status, and the functional status of tumor NLRP3 immunosomes plays an important role in regulating the tumor immune microenvironment, but whether they are involved in the regulation of immunosuppression in MSS patients is unclear ...
Li Lu, Menglin Wu, Xunzhen Jiang, Tong Liu, Weihua Fu, Weidong Li, Xue Li, Zhicheng Zhao   +7 more
wiley   +1 more source

Preoperative Clinical Predictors of Histologic Malignancy and Carcinoma Grade in 286 Canine Mammary Nodules from 92 Bitches: A Retrospective Study. [PDF]

Animals (Basel)
Fuertes-Recuero M, García San José P, Valdivia G, Suarez-Redondo M, Penelo S, Arenillas M, Camacho-Alonso L, Peña L, Pérez-Alenza D, Ortiz-Díez G.   +9 more
europepmc   +1 more source

Expanding the Anatomical Distribution of PRRX1::KMT2D Fusion Mesenchymal Neoplasms: A Rare Mediastinal Case Report

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background PRRX1‐rearranged mesenchymal neoplasms are rare soft tissue tumors with a predilection for the superficial subcutaneous tissue. The PRRX1::KMT2D fusion variant is exceptionally rare, with only three previously reported cases, all of which were located in the intermuscular regions.
Weixiang Zhong, Yu Deng, Ke Sun
wiley   +1 more source

Establishment and characterization of primary epithelial cell cultures from healthy canine mammary gland tissue. [PDF]

Front Vet Sci
Nosalova N, Huniadi M, Valencakova A, Hornakova L, Kalinaj B, Almasiova V, Marcincakova D, Kubatka P, Hornak S, Cizkova D.   +9 more
europepmc   +1 more source

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation. Studies suggest that compound cytotoxicity profiles in vitro vary depending on FCS concentration in culture medium. The study aimed to examine how extracellular conditions influence the in vitro
Sanele Priscillia Mathibela, Maphuti Tebogo Lebelo, Vanessa Steenkamp   +2 more
wiley   +1 more source

3D printed collimators and dosimetry for spatially fractionated radiation therapy. [PDF]

J Appl Clin Med Phys
Coon-Haworth MR, Geise JB, Elango T, Zaugg CJ, Veenstra JL, Riffell JJ, Polkowski A, Oderinde OM, Rivera JN, Scarpelli ML.   +9 more
europepmc   +1 more source

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source

Multi-omics profiling uncovers immune-molecular clusters with distinct chemo-immunotherapeutic vulnerabilities in a mouse model of triple-negative breast cancer. [PDF]

Mol Cancer
Castellanet O, Monatte J, Corvaisier N, Kaoutari AE, Kaya M, Ferreira L, Audebert S, Camoin L, de Nonneville A, Gonçalves A, Borg JP, Michea P, Maina F, Lamballe F.   +13 more
europepmc   +1 more source