Results 91 to 100 of about 88,076 (273)

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Cloning of an Infectious Milk-Borne Mouse Mammary Tumor Virus (MMTV) DNA from a Mammary Tumor That Developed in an Endogenous MMTV-Free Wild Mouse

, 2000
Molecular characterization of infectious mouse mammary tumor viruses (MMTVs) has been hampered due to the problem of cloning a full-length exogenous virus into a plasmid.
Xu, Lai, Tay, Chin H., Sarkar, Nurul H., Huber, Brigitte T.   +3 more
core   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source

Mouse Mammary Tumor Virus-Like Nucleotide Sequences in Canine and Feline Mammary Tumors

, 2010
Mouse mammary tumor virus (MMTV) has been speculated to be involved in human breast cancer. Companion animals, dogs, and cats with intimate human contacts may contribute to the transmission of MMTV between mouse and human.
Shyan-Song Chiou, Shih-Chieh Chang, Hsing-Yi Lin, Min-Liang Wong, Szu-Pong Wang, Wei-Li Hsu, Chao-Chin Chang, Songkhla Chulakasian, Kuan-Hsun Lin   +8 more
core   +2 more sources

Exacerbated metastatic disease in a mouse mammary tumor model following latent gammaherpesvirus infection

Infectious Agents and Cancer, 2012
Background Controversy exists as to the ability of human gammaherpesviruses to cause or exacerbate breast cancer disease in patients. The difficulty in conducting definitive human studies can be overcome by investigating developing breast cancer in a ...
Chauhan Vinita S, Nelson Daniel A, Roy Lopamudra Das, Mukherjee Pinku, Bost Kenneth L   +4 more
doaj   +1 more source

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

MedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li, Mingxia Deng, Leqing Zhu, Zhiwei Lei, Rong Guo, Xiong Liu, Renwang Chen, Xichun Xia, Qiong Wen, Yuanyuan Duan, Yan Chen, Zhinan Yin   +11 more
wiley   +1 more source

Mammary Tumor Virus Infections and Immunity

Mammary tumorigenesis appears to be influenced by several factors including genetic background, hormones and the immune response. In animal models there is a correlation between infection with mouse mammary tumor virus (MMTV) and an increased incidence ...
Lopez, Diana M., Paul, Ronald D., Pauley, Robert J.   +2 more
core   +1 more source

A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus

mBio, 2019
Complex human-pathogenic retroviruses cause high morbidity and mortality worldwide, but resist antiviral drugs and vaccine development due to evasion of the immune response.
Gurvani B. Singh, Hyewon Byun, Almas F. Ali, Frank Medina, Dennis Wylie, Haridha Shivram, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley   +8 more
doaj   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Hormone-responsive expression of an endogenous proviral gene of mouse mammary tumor virus after molecular cloning and gene transfer into cultured cells.

Proceedings of the National Academy of Sciences of the United States of America, 1981
A recombinant lambda phage containing mouse mammary tumor virus (MMTV) proviral DNA was isolated from a gene library constructed from GR mouse liver DNA.
N. Hynes, N. Kennedy, U. Rahmsdorf, B. Groner   +3 more
semanticscholar   +1 more source