Results 151 to 160 of about 64,031 (196)

Mouse mammary tumor virus and mammary tumorigenesis in wild mice

Pathology International, 1996
The current knowledge of the distribution of the mouse mammary tumor virus (MMTV) proviral genomes and the mechanism of mammary tumorigenesis by MMTV in mice, with the main emphasis on Asian feral mice, is reviewed. The relevant earlier discoveries on the mode of MMTV transmission are summarized to provide an outline of the biology of MMTV.
exaly   +3 more sources

Superantigens of Mouse Mammary Tumor Virus

Annual Review of Immunology, 1995
Superantigens (SAgs) are proteins of microbial origin that bind to major histocompatibility complex (MHC) class II molecules and stimulate T cells via interaction with the V beta domain of the T cell receptor (TCR). Mouse mammary tumor virus (MMTV) is a milk-transmitted type B retrovirus that encodes a SAg in its 3' long terminal repeat.
Acha-Orbea H, MacDonald HR
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Mouse Mammary Tumor Virus and the Immune System

Immunologic Research, 2003
Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells.
Jennifer, Czarneski, John C, Rassa, Susan R, Ross   +2 more
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The polypeptide composition of mouse mammary tumor virus

Virology, 1974
Abstract The polypeptide composition of mouse mammary tumor virus isolated from several strains of mice, has been examined by polyacrylamide gel electrophoresis. Gel Patterns, as revealed by staining and 14 C amino acid labelling, showed 10 polypeptide species reproducibly associated with the virus.
C, Dickson, J J, Skehel
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Surface structure of mouse mammary tumor virus

Virology, 1974
Abstract The structure of the envelope of mouse mammary tumor virus (MuMTV) was studied by using negative stain, thin sections and freeze-drying-shadowing. The surface of the viral membrane was found to contain a reticular structure composed mainly of hexagons and occasional pentagons. The spacing between the nearest corners was about 74 A. The viral
Sarkar, N H, Moore, D H
openaire   +2 more sources

Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains

Journal of Virology, 1978
The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained.
Michalides, R, Deemter, L V, Nusse, R, Ropcke, G, Boot, L   +4 more
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Selective amplification of mouse mammary tumor virus in mammary tumors of GR mice

Journal of Virology, 1980
DNAs extracted from the mammary tumors of GR mice were analyzed for mouse mammary tumor virus proviral sequences by the restriction enzyme-Southern blot procedure. The tumor DNAs contain more proviral copies of mouse mammary tumor virus than DNA from a nonmalignant tissue. The degree of proviral amplification is small (ca. one to five additional copies)
T G, Fanning, J P, Puma, R D, Cardiff
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Breast Cancer and Mouse Mammary Tumor Virus

Annals of Internal Medicine, 1983
Excerpt To the editor: The recent report by Poon and associates (1) provides additional evidence associating antigens of mouse mammary tumor virus with human breast cancer.
openaire   +2 more sources

Quantification of mouse mammary tumor virus structural proteins in hormone‐induced mammary tumors of low mammary tumor mouse strains

International Journal of Cancer, 1980
AbstractThe expression of the mouse mammary tumor virus (MMTV) in hormone‐induced mammary tumors was investigated by means of a radioimmunoassay for two major MMTV proteins, gp52 and p27. MMTV proteins were isolated on lectin affinity‐ and ion‐exchange chromatography columns. The purified viral proteins were electrophoretically homogeneous and retained
Nusse, R, Michalides, R, Boot, L M, Ropcke, G   +3 more
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Gene order of the mouse mammary tumor virus glycoproteins

Virology, 1977
Immunochemical and tryptic peptide mapping techniques were used to show that the mouse mammary tumor virus (MMTV) envelope glycoproteins gp52 and gp36 are distinct components derived from a common glycosylated precursor polypeptide of 75,000 daltons (gPr75). Because both gp52 and gp36 are derived from a common precursor polypeptide and therefore have a
G, Schochetman, S, Oroszlan, L, Arthur, D, Fine   +3 more
openaire   +2 more sources