Results 51 to 60 of about 419,920 (305)
Scientific Reports, 2021 Feline mammary carcinoma (FMC) shows great similarities to human breast cancer in the cellular and molecular levels. So, in cats as in humans, the role of immune responses is indicated to detect and follow up the development of tumors.
Asmaa M. El-Rasikh +7 more
doaj +1 more source
Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]
, 2015 BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD +5 more
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
BMC Cancer, 2014 Background Data from in vivo and in vitro studies suggest that activation of Akt regulates cell survival signaling and plays a key role in tumorigenesis.
Yanyuan Wu +4 more
doaj +1 more source
Semina: Ciências Agrárias, 2019 The canine mammary tumor is the neoplasia that most commonly affects intact female dogs (not spayed) in routine veterinary practice. Canine mammary tumor therapy is a challenge because only few effective treatments have been described for high-grade ...
Analy Ramos Mendes Ferrari +5 more
doaj +1 more source
Expression of tumour transcription factor GLI1 in canine mammary tumours tissue
Veterinary Medicine and Science, 2022 Background Mammary tumor is one of the most common diseases of canine in pet clinics. Objectives This study investigates the distribution and expression of the tumor transcription factor GLI1 and the downstream proteins, Bmi1 and Sox2, in canine mammary ...
Penggang Liu +5 more
doaj +1 more source
Epidemiological Investigation of Canine Mammary Tumors in Mainland China Between 2017 and 2021
Frontiers in Veterinary Science, 2022 Epidemiological studies enable us to analyze disease behavior, define risk factors, and establish fundamental prognostic criteria. This study aimed to determine the epidemiological and clinical characteristics of canine tumors diagnosed during the years ...
Hui-Hua Zheng +6 more
doaj +1 more source
SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities [PDF]
, 2019 Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the ...
Botti L. +12 more
core +3 more sources
Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors [PDF]
Molecular and Cellular Biology, 2003 Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-kappaB subunit, has been reported in solid and hematopoietic malignancies. For example, many primary human breast cancer tissue samples express high levels of nuclear c-Rel. While the Rev-T oncogene v-rel causes tumors in birds, the ability of c-Rel to transform in
Raphaëlle, Romieu-Mourez +7 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source