Results 31 to 40 of about 4,503 (207)

Repression of WT1-Mediated LEF1 Transcription by Mangiferin Governs β-Catenin-Independent Wnt Signalling Inactivation in Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2018
Background/Aims: The development of hepatocellular carcinoma (HCC) is a complex process which involves deregulation of multiple signalling pathways. The hyper-activation of Wnt signalling promotes sustained expansion, invasion, and neovascularization of ...
Hor-Yue Tan, Ning Wang, Sha Li, Ming Hong, Wei Guo, Kwan Man, Chien-shan Cheng, Zhen Chen, Yibin Feng   +8 more
doaj   +1 more source

Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion

Frontiers in Pharmacology, 2020
Hyperuricemia is characterized by abnormally high level of circulating uric acid in the blood and is associated with increased risk of kidney injury. The pathophysiological mechanisms leading to hyperuricemic nephropathy (HN) involve oxidative stress ...
Xuechen Li, Xuechen Li, Zhenxin Yan, Mattias Carlström, Jinying Tian, Xiaolin Zhang, Wenxuan Zhang, Song Wu, Fei Ye   +8 more
doaj   +1 more source

Mangiferin ve Kanser

Journal of Nutrition and Dietetics, 2019
Kanser, kontrolsüz ve anormal hücre çoğalması ile karakterize bir hastalıktır. Birçok yeni antikanser ilacı piyasada bulunmasına rağmen, çoğu zayıf biyoyararlanım, yüksek maliyet ve amaçlanmayan yan etkilerden dolayı hayati endişelere neden olmaktadır.
Fatmanur Hümeyra Zengin, Gamze Akbulut
openaire   +4 more sources

Mangiferin modulation of metabolism and metabolic syndrome [PDF]

BioFactors, 2016
AbstractThe recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. Natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics.
Ekaterina Vladimirovna, Fomenko, Yuling, Chi   +1 more
openaire   +2 more sources

Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives

, 2022
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking ...
Golam Mahbub Faisal, Md Jamal Uddin, Sumaya Akter, Akhi Moni, Muhammad Ramiz Uddin, Nourin Jahan, Md Abdul Hannan, Asadur Rahman   +7 more
core   +1 more source

Quantification of mangiferin by high pressure liquid chromatography; physicochemical and sensory evaluation of functional mangiferin drink

, 2016
The current research project was an attempt to extract and quantify mangiferin contents from mango peel and to evaluate its storage stability in functional drinks.
S Akhtar (13604140), M Riaz (7713659), Hafiz Suleria (13096467), MS Butt (14463234), M Imran (12678580), MJ Iqbal (14867269)   +5 more
core   +2 more sources

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation [PDF]

, 2016
Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation.
和田, 政裕, 中谷, 祥恵, 清水, 純, 小倉, 香名, 君羅, 好史, 江端, みどり, 関口, 祐介, 片岡, 綾, 真野, 博   +8 more
core   +1 more source

Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains

Molecules, 2011
The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1ⅢB induced syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration (EC50) at 16.90 μM and a therapeutic index (TI) above 140. Mangiferin also
Rui-Rui Wang, Yue-Dong Gao, Chun-Hui Ma, Xing-Jie Zhang, Cheng-Gang Huang, Jing-Fei Huang, Yong-Tang Zheng   +6 more
doaj   +1 more source

Inhibitory Potential of Mangiferin on Glucansucrase Producing Streptococcus mutans Biofilm in Dental Plaque

Applied Sciences, 2020
Glucansucrase secreted by Streptococcus mutans and composed of virulence genes alters oral microbiota, creating adherent environment for structural bacteria colony forming dental biofilm.
Promise M. Emeka, Lorina I. Badger-Emeka, Hairul-Islam M. Ibrahim, Krishnaraj Thirugnanasambantham, Jamal Hussen   +4 more
doaj   +1 more source

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

Pharmaceutics, 2021
Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed.
Maddalena Sguizzato, Francesca Ferrara, Paolo Mariani, Alessia Pepe, Rita Cortesi, Nicolas Huang, Fanny Simelière, Paola Boldrini, Anna Baldisserotto, Giuseppe Valacchi, Elisabetta Esposito   +10 more
doaj   +1 more source