Results 291 to 300 of about 89,044 (334)
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Mannose binding lectin (MBL) and HIV
Molecular Immunology, 2005The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody responses to the virus, it also provides a potential site of attack by the innate immune system ...
Gregory T. Spear, Henry Gewurz, Xin Ji
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Mannose‐binding lectin and innate immunity
Immunological Reviews, 2009Summary: Innate immunity is the earliest response to invading microbes and acts to contain infection in the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal expansion of cells that emerge days after antigenic challenge, the innate immune response is immediate.
Kazue Takahashi +3 more
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Mannose‐binding lectin and vulvovaginal candidiasis
International Journal of Gynecology & Obstetrics, 2005AbstractObjective: To investigate the effect of mannose‐binding lectin (MBL) gene polymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC). Patients and methods: Mannose‐binding lectin concentrations in CVL samples from 111 women were collected ...
Zhaohui Liu, Fei Liu, Qinping Liao
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Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases.
Current Medicinal Chemistry, 2016The innate immune system plays a modulatory role in producing an inflammatory response during microbial infection and tissue regeneration. Mannose-binding lectin (MBL) is a predominant constituent of the innate immune system which initiates one of the ...
S. Singh, R. Cheung, J. Wong, T. Ng
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Effect of branching density on avidity of hyperbranched glycomimetics for mannose binding lectin.
Biomacromolecules, 2013Hyperbranched glycopolymers containing mannose units in the branch point were synthesized through the copolymerization of a mannose inimer and mannose acrylate via atom transfer radical polymerization (ATRP).
Kenneth Lin, A. Kasko
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In silico improvement of the cyanobacterial lectin microvirin and mannose interaction
Journal of Biomolecular Structure and Dynamics, 2020Lectins that bind to HIV envelope glycoprotein can inhibit virus-cell fusion and be used for rational drug design. This paper presents the results of an in silico approach to improve affinity interaction between the cyanobacterial lectin microvirin and ...
Adonis de Melo Lima +9 more
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Mannose‐binding lectin levels in children with asthma
Pediatric Allergy and Immunology, 2005Mannose‐binding lectin (mbl), one of the important components of innate immunity, can activate the lectin pathway of the complement system. After binding mannose containing carbohydrate structures of foreign antigen, mbl initiates and regulates the inflammatory responses. Asthma is a complex inflammatory disease of the lung involving many components of
S. Halide Akbas +4 more
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Mannose-binding lectin and meningococcal disease
The Lancet, 1999Kuijper, E J +3 more
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Mannose binding lectin gene polymorphisms and asthma
Clinical & Experimental Allergy, 2007SummaryBackground Bronchial asthma is a chronic inflammatory disorder of the airways. Recently, it has been suggested that complement plays significant roles in asthma. Mannose‐binding lectin (MBL) is one of the key molecules in complement activation pathways that are associated with several infectious and immune disorders.Subjects and method
Xintao Wang +5 more
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Plasma mannose-binding lectin is stimulated by PPARα in humans.
American Journal of Physiology. Endocrinology and Metabolism, 2012The peroxisome proliferator activated receptor-α (PPARα) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPARα on lipid metabolism are partially mediated by
M. Rakhshandehroo +7 more
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