Results 31 to 40 of about 61,632 (321)
The ‘involution’ of mannose-binding lectin [PDF]
Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich backbone structure of the protein.
Hans O. Madsen+2 more
openaire +3 more sources
Activity of mannose‐binding lectin in centenarians [PDF]
SummaryWe analyzed MBL2 gene variants in two cohorts of centenarians, octo‐nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity.
TOMAIUOLO, R+12 more
openaire +5 more sources
Mannose-binding lectins effectively inhibit most seasonal strains of influenza A virus and contribute to the innate host defense vs. these viruses. In contrast, pandemic IAV strains are largely resistant to these lectins, likely contributing to increased
Mitchell R. White+6 more
doaj +1 more source
Heterogeneity in glycan composition on the surface of HIV-1 envelope determines virus sensitivity to lectins. [PDF]
Lectins that target N-glycans on the surface of HIV-1 envelope (Env) glycoprotein have the potential for use as antiviral agents. Although progress has been made in deciphering the molecular details of lectin and Env glycan interaction, further studies ...
Muzafar Jan+4 more
doaj +1 more source
Mannose‐binding lectin and gastric cancer [PDF]
Daniel L. Worthley*, Peter G. Bardy, David L. Gordon and Charles G. Mullighan Department of Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia Division of Hematology, Royal Adelaide Hospital and Institute of Medical and Veterinary Science, South Australia, Australia Department of Hematology–Oncology, The Queen ...
Daniel L. Worthley+4 more
openaire +4 more sources
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog+12 more
wiley +1 more source
Mannose-Binding Lectin and Susceptibility to Schistosomiasis [PDF]
Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as ...
Olusola Ojurongbe+10 more
openaire +4 more sources
Mannose-Binding Lectin in HIV Infection [PDF]
Infection with HIV represents a significant global health problem, with high infection rates and high mortality worldwide. Treatment with antiretroviral therapy is inaccessible to many patients and efficacy is limited by development of resistance and side effects.
A Dzwonek, Sarah Eisen, Nigel Klein
openaire +3 more sources
Seaweed lectins, especially high-mannose-specific lectins from red algae, have been identified as potential antiviral agents that are capable of blocking the replication of various enveloped viruses like influenza virus, herpes virus, and HIV-1 in vitro.
Annick Barre+4 more
doaj +1 more source
Mannose-Binding Lectin and Liver Transplantation [PDF]
Daniel L. Worthley+4 more
openalex +3 more sources