Results 31 to 40 of about 15,589 (264)

Covalent Activation of the C-type Lectin DC-SIGN. [PDF]

Angew Chem Int Ed Engl
We introduce the first covalent activators of a C‐type lectin. Using orthogonal functional assays, NMR, MS/MS, and computational modeling, we delineate mechanisms from a functional electrophile‐first screen on dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) that yields two modes: N‐hydroxysuccinimide (NHS ...
Lefèbre J, Besch M, Csorba N, Garami K, Orgován Z, Schlosser G, Bermejo I, Ábrányi-Balogh P, Keserű GM, Rademacher C.   +9 more
europepmc   +2 more sources

Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity.

PLoS Pathogens, 2011
Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia, which has two distinct
Ondřej Sulák, Gianluca Cioci, Emilie Lameignère, Viviane Balloy, Adam Round, Irina Gutsche, Lenka Malinovská, Michel Chignard, Paul Kosma, Daniel F Aubert, Cristina L Marolda, Miguel A Valvano, Michaela Wimmerová, Anne Imberty   +13 more
doaj   +1 more source

Bone healing and Mannose-Binding Lectin

International Journal of Surgery, 2013
Non-union of a fracture is a phenomenon that may complicate bone healing. Consolidation of a fracture can be divided into three phases: inflammation, reconstruction, and remodeling. Both the complement system and the coagulation cascade interact at various steps throughout these phases. Several complement components are specifically associated with the
Ende, J. van der, Baardewijk, L.J. van, Sier, C.F.M., Schipper, I.B.   +3 more
openaire   +3 more sources

Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies

Angewandte Chemie, EarlyView.
Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod, Ajay S. Thatte, Rohan Palanki, Michael J. Mitchell   +3 more
wiley   +2 more sources

Adenovirus Carrying Gene Encoding Haliotis discus discus Sialic Acid Binding Lectin Induces Cancer Cell Apoptosis

Marine Drugs, 2014
Lectins exist widely in marine bioresources such as bacteria, algae, invertebrate animals and fishes. Some purified marine lectins have been found to elicit cytotoxicity to cancer cells.
Xinyan Yang, Liqin Wu, Xuemei Duan, Lianzhen Cui, Jingjing Luo, Gongchu Li   +5 more
doaj   +1 more source

Characterization and antimicrobial activity of lectins purified from three Egyptian leguminous seeds

AMB Express, 2020
Lectins are carbohydrate-binding proteins that play vital roles in many biological processes. In this study, lectins from three Egyptian cultivars (fava bean, lentil, and pea) were isolated by precipitation with different concentrations of ammonium ...
Magda M. El-Araby, Einas H. El-Shatoury, Mervat M. Soliman, Hanan F. Shaaban   +3 more
doaj   +1 more source

A Keratin Peptide Inhibits Mannose-Binding Lectin [PDF]

The Journal of Immunology, 2001
Abstract Complement plays a significant role in mediating endothelial injury following oxidative stress. We have previously demonstrated that the lectin complement pathway (LCP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for activating complement on endothelial cells following periods of
M C, Montalto, C D, Collard, J A, Buras, W R, Reenstra, R, McClaine, D R, Gies, R P, Rother, G L, Stahl   +7 more
openaire   +2 more sources

Mannose-Binding Lectin and Susceptibility to Schistosomiasis [PDF]

The Journal of Infectious Diseases, 2013
Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as ...
Justin S, Antony, Olusola, Ojurongbe, Hoang, van Tong, Eman Abou, Ouf, Thomas, Engleitner, Akeem A, Akindele, Olawumi R, Sina-Agbaje, Adegboyega O, Adeyeba, Peter G, Kremsner, Thirumalaisamy P, Velavan   +9 more
openaire   +3 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source