Results 111 to 120 of about 102,260 (189)
Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies
Chemistry &Biodiversity, EarlyView.Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang +8 more
wiley +1 more source
Disruption of Retriever Function Impacts Retrograde Trafficking From Endosomes
Cell Biology International, EarlyView.ABSTRACT Within endosomes cargo proteins are sorted and packaged into endosomal‐transport carriers (ETCs) enabling their delivery to other intracellular compartments. Retromer, a conserved multimeric protein complex, has defined functions in sorting cargo mediating formation of ETCs for both retrograde trafficking back to the trans‐Golgi network (TGN ...
Zebin Li, Zhe Yang, Rohan D. Teasdale
wiley +1 more source
ChemCatChem, EarlyView.Three series of titania–Cu photocatalysts have been prepared and tested for hydrogen generation by cellulose photo‐reforming. Copper was incorporated, by impregnation, in P25 (a) and in hydrothermally synthesized TiO2 (b), and also by a one‐pot hydrothermal synthesis (c).
Sergio Belda‐Marco +2 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková +11 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A novel family of water‐soluble, nontoxic, and phosphorescent N‐glycosylated Ru(II) phenanthroline‐based complexes are reported. They exhibit photoselectivity indexes ranging from 10 to 44 in PC‐3 cells, while impacting cell migration and resistance to detachment after irradiation with blue light.
Elena de la Torre‐Rubio +5 more
wiley +1 more source
The Synthesis of Aryl‐β‐C‐Glycosides from Native Saccharides
Chemistry – A European Journal, EarlyView.Native mono‐, di‐, and trisaccharides are converted into p‐nitrophenol‐β‐C‐glycosides in a one‐pot reaction using water as the solvent. A sequence of condensation reactions is used to construct the aromatic ring from acyclic precursors. Using this approach, a modular synthesis of SGLT2‐inhibitor scaffolds was developed and applied to a novel protecting‐
Daan V. Bunt +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.The stereochemical diversity of the “glycan code” enables similar chiral motifs to arise from both D‐ and L‐sugars. Focused on DC‐SIGN–glycan recognition, two diverse monosaccharide scaffolds, D‐Man (D‐Rha) and L‐Gal (L‐Fuc), maintain the exquisite stereochemistry encoded in the minimal binding epitope.
J. Daniel Martínez +7 more
wiley +1 more source
Carbohydrate Wastes to Chemicals (CtC): From Second‐Generation Sugars to Glycols
Chemie Ingenieur Technik, EarlyView.The Carbohydrate Wastes to Chemicals (CtC) project examined an alternative and sustainable route to the production of glycols with propylene glycol as the main product. Thereby, the utilization of carbohydrate‐containing residues as second‐generation sugars was researched as alternative biogenic feedstock from biomass.
Giuseppe Cusati +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost +9 more
wiley +1 more source
Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis
ChemSusChem, Volume 18, Issue 6, March 15, 2025.The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo +4 more
wiley +1 more source