Results 71 to 80 of about 102,260 (189)

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]

, 2020
The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua, Kirkemo, Lisa, Leung, Kevin, Riley, Nicholas, Wells, James, Wilson, Gary   +5 more
core  

Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin [PDF]

, 2002
Background— The possible association between coronary artery disease (CAD) and Chlamydia pneumoniae (C pneumoniae) infection is controversial. On the basis of the recent suggestion that mannose-binding lectin (MBL) variant alleles are related to an ...
Burián, Katalin, Duba, Jenő, Endrész, Valéria, Füst, György, Garred, Peter, Gönczöl, Éva, Karádi, István, Madsen, Hans O., Prohászka, Zoltán, Romics, László, Rugonfalvi-Kiss, Szabolcs   +10 more
core   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]

, 2018
This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R, Lee, Keunsook, Mukaremera, Liliane, Nielsen, Kirsten, Wagener, Jeanette, Wiesner, D. L.   +5 more
core   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Recent insights into structures and functions of C-type lectins in the immune system [PDF]

, 2015
The majority of the C-type lectin-like domains in the human genome likely to bind sugars have been investigated structurally, although novel mechanisms of sugar binding are still being discovered.
Drickamer, K, Taylor, ME
core   +1 more source

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Advanced Science, EarlyView.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu   +6 more
wiley   +1 more source

Unnatural Triggers Converted From Tetrazine‐Attached Sialic Acid for Activation of Optoacoustic Imaging‐Guided Cancer Theranostics

Angewandte Chemie, EarlyView.
Tetrazine precursors (SiaTz) based on a nonO‐acetylated sialic acid scaffold are rationally designed and synthesized, which can be efficiently converted into unnatural tetrazine (Tz) triggers on cancer cell surfaces via metabolic glycoengineering. These Tz triggers activate theranostic agents for multispectral optoacoustic tomographic (MSOT) imaging ...
Yinglong Wu, Lihe Sun, Xiaodong Zhang, Wenbin Zhong, Xiaokai Chen, Shihuai Wang, Yun Chen, Dongdong Wang, Ting He, Hongzhong Chen, Jingjing Guo, Fang Zeng, Menghuan Li, Zhong Luo, Shuizhu Wu, Yanli Zhao   +15 more
wiley   +2 more sources