Results 101 to 110 of about 2,479,436 (371)

D-mannose suppresses the angiogenesis and progression of colorectal cancer

Acta Biochimica et Biophysica Sinica
Angiogenesis is an important factor influencing the development of solid tumors, and vascular endothelial growth factor receptor-2 (VEGFR2) is a central regulator of angiogenesis.
Du Yu, Zhang Xinchao, Xu Yixin, Zhou Yuefan, Xu Yanping   +4 more
doaj   +1 more source

Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis*

Journal of Biological Chemistry, 2014
Background: Mannose receptor family members are candidate mediators of intracellular collagen degradation. Results: Despite common candidate collagen-binding domains and endocytic capacity throughout the family, only uPARAP/Endo180 and MR internalize ...
H. J. Jürgensen, K. Johansson, D. H. Madsen, Astrid Porse, Maria C Melander, K. R. Sørensen, Christoffer Nielsen, T. Bugge, N. Behrendt, L. Engelholm   +9 more
semanticscholar   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells.

PLoS ONE, 2007
BackgroundAn experimental approach for improving vaccine efficacy involves targeting antigens to mannose receptors (MRs) on dendritic cells (DCs) and other professional antigen presenting cells.
Jennifer S Lam, Haibin Huang, Stuart M Levitz   +2 more
doaj   +1 more source

MRC1 (mannose receptor, C type 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on MRC1 (mannose receptor, C type 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Rasi, S, Bruscaggin, A, Gaidano, G
openaire   +2 more sources

Distribution of glycan motifs at the surface of midgut cells in the cotton leafworm (Spodoptera littoralis) demonstrated by lectin binding [PDF]

, 2017
Glycans are involved in many biological phenomena, including signal transduction, cell adhesion, immune response or differentiation. Although a few papers have reported on the role of glycans in the development and proper functioning of the insect midgut,
Els J. M. Van Damme, Guy Smagghe, Kaat Cappelle, Kristof De Schutter, Tomasz Walski, Tomasz Walski   +5 more
core   +2 more sources

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cellsKey findings

Materials Today Bio
Dendritic cells (DCs) have emerged as a promising target for drug delivery and immune modulation due to their pivotal role in initiating the adaptive immune response.
Meshal A. Alobaid, Sarah-Jane Richards, Morgan R. Alexander, Matthew I. Gibson, Amir M. Ghaemmaghami   +4 more
doaj   +1 more source