Small Methods, EarlyView.Design of an injectable porous hydrogel modulating macrophages and their secreted EVs for joint defect repair in the pathology of rheumatoid arthritis. a) The solution containing HA and CS‐MOS, upon mixing with a crosslinker solution, undergoes porous hydrogel formation with the escape of generated CO₂ gas.
Anan Zhang +9 more
wiley +1 more source
Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP. [PDF]
RSC Adv, 2021 Xiao H, Han S, Baigude H.
europepmc +1 more source
Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes. [PDF]
, 1996 Dagmar Kasper +3 more
openalex +1 more source
Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers
Small Methods, EarlyView.Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz +5 more
wiley +1 more source
Macrophages exploit the mannose receptor and JAK-STAT1-MHC-II pathway to drive antigen presentation and the antimycobacterial immune response after BCG vaccination. [PDF]
Acta Biochim Biophys Sin (Shanghai)Zhang Y +8 more
europepmc +1 more source
Chronology of Events Accompanying Follicular Atresia in Hypophysectomized Ewes. Changes in Levels of Steroidogenic Enzymes, Connexin 43, Insulin-Like Growth Factor II/Mannose 6 Phosphate Receptor, Extracellular Matrix Components, and Matrix Metalloproteinases1 [PDF]
, 1998 Clotilde Huet +5 more
openalex +1 more source
Small Structures, EarlyView.Galectin‐10 crystals prepared by cell‐free protein crystallization serve as the scaffold to capture the saccharides to determine the atomic‐resolution structure of a trisaccharide bound to protein. Molecular dynamics simulation combined with the mutation of scaffold crystals offers insights into how the binding site architecture modulates saccharide ...
Mariko Kojima +7 more
wiley +1 more source
Macrophage Activation Markers, Soluble CD163 and Mannose Receptor, in Liver Fibrosis. [PDF]
Front Med (Lausanne), 2020 Gantzel RH +6 more
europepmc +1 more source
The Rate of Internalization of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is Enhanced by Multivalent Ligand Binding [PDF]
, 1999 Sally J. York +4 more
openalex +1 more source
Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems
ChemSystemsChem, EarlyView.This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis +4 more
wiley +1 more source