Results 71 to 80 of about 2,415,950 (382)

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice

Journal of Inherited Metabolic Disease, 2015
Enzyme replacement therapy (ERT) is an effective treatment for several lysosomal storage disorders (LSDs). Intravenously infused enzymes are taken up by tissues through either the mannose 6-phosphate receptor (M6PR) or the mannose receptor (MR).
Jinsong Shen, A. Busch, Taniqua S. Day, Xing‐Li Meng, Chun I Yu, Paulina Dabrowska-Schlepp, Benjamin Fode, Holger Niederkrüger, S. Forni, Shuyuan Chen, R. Schiffmann, T. Frischmuth, A. Schaaf   +12 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Probing multivalency in ligand–receptor-mediated adhesion of soft, biomimetic interfaces

Beilstein Journal of Organic Chemistry, 2015
Many biological functions at cell level are mediated by the glycocalyx, a dense carbohydrate-presenting layer. In this layer specific interactions between carbohydrate ligands and protein receptors are formed to control cell–cell recognition, cell ...
Stephan Schmidt, Hanqing Wang, Daniel Pussak, Simone Mosca, Laura Hartmann   +4 more
doaj   +1 more source

M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1

Cell Reports, 2017
Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown.
Murugesan V.S. Rajaram, Eusondia Arnett, Abul K. Azad, Evelyn Guirado, Bin Ni, Abigail D. Gerberick, Li-Zhen He, Tibor Keler, Lawrence J. Thomas, William P. Lafuse, Larry S. Schlesinger   +10 more
doaj   +1 more source

Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations.

PLoS ONE, 2020
The presence of a high number of macrophages within solid tumors is often significantly associated with poor prognosis and predict treatment failure for chemotherapy and radiotherapy.
Luciana Kovacs, Pablo Cabral, Roger Chammas   +2 more
doaj   +1 more source

Tissue Levels of CD80, CD163 and CD206 and Their Ratios in Periodontal and Peri-Implant Health and Disease

Current Issues in Molecular Biology, 2022
This study aimed to compare tissue levels of CD80 (pro-inflammatory macrophage-related surface marker), CD163, and CD206 (anti-inflammatory macrophage-related surface markers), and their ratios in periodontal and peri-implant health and disease ...
Mustafa Yilmaz, Esra Demir, Yigit Firatli, Erhan Firatli, Ulvi Kahraman Gürsoy   +4 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications [PDF]

, 2014
In this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with ...
Abbott, Agarwal, Agashe, Agashe, Agrawal, Agrawal, Albersheim, Albertazzi, Amir, Anajwala, Andre, Andre, Andre, Anna Janaszewska, Antoni, Antoni, Aoi, Appelhans, Appelhans, Arima, Arima, Arima, Arima, Arima, Baek, Baigude, Baigude, Baker, Bandaru, Barbara Klajnert-Maculewicz, Barner-Kowollik, Bettinger, Bhadra, Bhadra, Boas, Bogdan, Bogdan, Bojarova, Borges, Boye, Branco de Barros, Branderhorst, Branson, Brigitte Voit, Calderon, Carlmark, Carlmark, Chabre, Chabre, Chabre, Chen, Chen, Cheng, Cheng, Choudhury, Ciepluch, Ciolkowski, Ciolkowski, Cloninger, Conte, Cook, Cummins, Danishefsky, de Paz, Diebold, Dietmar Appelhans, Dolenc, Dominguez, Dondoni, Drzewinska, Duncan, Duncan, Dutta, Dutta, Dutta, Dutta, Ennen, Erbacher, Fajac, Filimon, Fischer, Franiak-Pietryga, Gabius, Gajbhiye, Gajbhiye, Gajbhiye, Gajbhiye, Gajbhiye, Garcia-Vallejo, Garg, Ghirardello, Gorelik, Gorityala, Gringas, Grobarova, Grosse, Grosse, Grosse, Gupta, Gupta, Gutsch, Hatano, Hauptmann, Hauptmann, He, Hu, Höbel, Iha, Ikeda, Imberty, Ina, Jain, Jain, Jain, Jain, Jain, Jain, Janaszewska, Janaszewska, Jararaman, Jararaman, Jayaraman, Jia, Joanna Lazniewska, Kade, Kaminskas, Kantchev, Kempe, Kensinger, Kensinger, Kesharwani, Kiessling, Kihara, Kihara, Kim, Klajnert, Klajnert, Klajnert, Klajnert, Klajnert, Klementieva, Klementieva, Kottari, Krist, Ku, Kuhlbeil, Kumar, Kunath, Kuo, Kuo, Kurmi, Köth, Laurino, Leclercq, Lee, Li, Lindhorst, Liu, Liu, Llinares, Lopez-Marin, Ma, Majoinen, Malik, Maly, Mangold, Marradi, Martos, Martínez, Matsushita, Matsushita, McCarthy, McCarthy, McCarthy, McCarthy, McNermy, Medina, Medina, Medina, Mignani, Mignani, Mignani, Mignani, Milowska, Misra, Mkandawire, Monsigny, Motoyama, Nahar, Narayan, Needham, Nepogodiev, Nicolas, Niederhafener, Niederhafener, Niederhafener, Ogiso, Oka, Oka, Ottaviani, Palcic, Paolino, Paolino, Papadopoulos, Park, Park, Park, Park, Patel, Pedziwiatr-Werbicka, Percec, Polikarpov, Richter, Robb, Ross, Roy, Roy, Roy, Roy, Rudd, Röckendorf, Sakamoto, Santoyo-Gonzáles, Santoyo-Gonzáles, Sapsford, Sashiwa, Satoh, Schengrund, Seah, Sethi, Shah, Sharma, Sharon, Shaunak, Shcharbin, Shiao, Sinha, Solassol, Stefani, Sun, Supattapone, Svenson, Svenson, Szewczyk, Szulc, Szulc, Tekade, ten Brummelhuis, Thünemann, Ting, Touaibia, Tripp, Tsutsumiuchi, Turnbull, Vacas Córdoba, Vepŕek, Wada, Wada, Walter, Wang, Wang, Wang, Warenda, Wasiak, Wijagkanalan, Wolfenden, Woller, Wood, Wu, Wu, Zanini, Zanini, Zanta, Zhang, Ziemba, Ziemba, Ziemba, Ziemba, Zinselmeyer   +278 more
core   +2 more sources

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source