Results 1 to 10 of about 4,411 (138)

Biochemical characterization of the α-1,3-mannosidase AnGH92A from Aspergillus nidulans [PDF]

Scientific Reports
α-Mannan is a structurally diverse polysaccharide widely distributed in fungi, yet the eukaryotic enzymes responsible for its degradation remain poorly understood.
Ryutaro Nishigaki, Hiromitsu Suzuki, Ryohei Tsukada, Ken Miyazawa, Masashi Kato, Motoyuki Shimizu   +5 more
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Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives [PDF]

Beilstein Journal of Organic Chemistry, 2023
A synthesis of 1,4-imino-ᴅ-lyxitols and their N-arylalkyl derivatives altered at C-5 is reported. Their inhibitory activity and selectivity toward four GH38 α-mannosidases (two Golgi types: GMIIb from Drosophila melanogaster and AMAN-2 from ...
Martin Kalník, Sergej Šesták, Juraj Kóňa, Maroš Bella, Monika Poláková   +4 more
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The diverse N-glycosylation profiles of CD4+CD25- and CD4+CD25+ T cells in Hashimoto’s thyroiditis [PDF]

Frontiers in Immunology
Hashimoto’s thyroiditis (HT) is one of the most common organ-specific autoimmune diseases, characterized by chronic thyroid gland inflammation. Helper T (Th) CD4+ cells, whose surface receptors are highly glycosylated, are involved in the pathomechanism ...
Sara Trzos, Sara Trzos, Marta Szewczyk, Paweł Link-Lenczowski, Paweł Link-Lenczowski, Grzegorz Sokołowski, Małgorzata Trofimiuk-Müldner, Katarzyna Bocian, Ewa Pocheć   +8 more
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A twin xanthan lyase-dependent xanthan degradation system in Paenibacillus taichungensis I5 [PDF]

Applied Microbiology and Biotechnology
Xanthan gum, a natural heteropolysaccharide produced by Xanthomonas species, has many biotechnological applications across industries due to its unique rheological properties.
Rui Han, Melanie Baudrexl, Oliver Frank, Christina Ludwig, Oksana V. Berezina, Sergey V. Rykov, Wolfgang Liebl   +6 more
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Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharide [PDF]

Scientific Reports
Microglia are the immune cells in the central nervous system (CNS) and become pro-inflammatory/activated in Alzheimer’s disease (AD). Cell surface glycosylation plays an important role in immune cells; however, the N-glycosylation and glycosphingolipid ...
Xinyu Tang, Ryan Lee Schindler, Jacopo Di Lucente, Armin Oloumi, Jennyfer Tena, Danielle Harvey, Carlito B. Lebrilla, Angela M. Zivkovic, Lee-Way Jin, Izumi Maezawa   +9 more
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Candida albicans Mannosidases, Dfg5 and Dcw1, Are Required for Cell Wall Integrity and Pathogenesis [PDF]

Journal of Fungi
Candida albicans is an oral mucosal commensal fungus that transforms into an opportunistic pathogen under specific conditions, including immunosuppression. It causes oral and systemic candidiasis, which results in a significant health burden. Furthermore,
Maryam Razmi, Jaewon Kim, Jennifer Chinnici, Sujay Busarajan, Hema Vuppalapaty, Deepika Lankipalli, Rui Li, Abhiram Maddi   +7 more
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Generating and characterizing a comprehensive panel of CHO cells glycosylation mutants for advancing glycobiology and biotechnology research [PDF]

Scientific Reports
This report describes the development and characterization of a comprehensive collection of CHO cell glycosylation mutants with significant potential for advancing glycobiology and biotechnology. EPO-Fc and trastuzumab, two model molecules, were produced
Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh, Zhiwei Song   +9 more
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Analysis of the galactomannan binding ability of β-mannosidases, BtMan2A and CmMan5A, regarding their activity and synergism with a β-mannanase

Computational and Structural Biotechnology Journal, 2022
Both β-mannanases and β-mannosidases are required for mannan-backbone degradation into mannose. In this study, two β-mannosidases of glycoside hydrolase (GH) families 2 (BtMan2A) and 5 (CmMan5A) were evaluated for their substrate specificities and ...
Samkelo Malgas, Mariska Thoresen, Vuyani Moses, Earl Prinsloo, J. Susan van Dyk, Brett I. Pletschke   +5 more
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Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition

Frontiers in Molecular Biosciences, 2023
N-glycosylation is a key process for various biological functions like protein folding, maturation and sorting for the conventional secretory compartment, cell-cell communication and immune response.
Cristian V. A. Munteanu, Gabriela N. Chirițoiu, Andrei-Jose Petrescu, Ștefana M. Petrescu   +3 more
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Bagasse minority pathway expression: Real time study of GH2 β-mannosidases from bacteroidetes.

PLoS ONE, 2021
After being isolated from a sugarcane pile, the bacterium Chitinophaga sp. CB10 demonstrated to be a rich source of carbohydrases, with 350 predicted CAZyme domains.
Tatiane Fernanda Leonel, Elisângela Soares Gomes Pepe, Tereza Cristina Luque Castellane, Juliana da Silva Vantini, Michelli Inácio Gonçalves Funnicelli, Eliana Gertrudes de Macedo Lemos   +5 more
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